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Expansion, in vivo-ex vivo cycling, and genetic manipulation of primary human hepatocytes.
Michailidis E, Vercauteren K, Mancio-Silva L, Andrus L, Jahan C, Ricardo-Lax I, Zou C, Kabbani M, Park P, Quirk C, Pyrgaki C, Razooky B, Verhoye L, Zoluthkin I, Lu WY, Forbes SJ, Chiriboga L, Theise ND, Herzog RW, Suemizu H, Schneider WM, Shlomai A, Meuleman P, Bhatia SN, Rice CM, de Jong YP. Michailidis E, et al. Among authors: herzog rw. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1678-1688. doi: 10.1073/pnas.1919035117. Epub 2020 Jan 8. Proc Natl Acad Sci U S A. 2020. PMID: 31915293 Free PMC article.
Next generation of adeno-associated virus 2 vectors: point mutations in tyrosines lead to high-efficiency transduction at lower doses.
Zhong L, Li B, Mah CS, Govindasamy L, Agbandje-McKenna M, Cooper M, Herzog RW, Zolotukhin I, Warrington KH Jr, Weigel-Van Aken KA, Hobbs JA, Zolotukhin S, Muzyczka N, Srivastava A. Zhong L, et al. Among authors: herzog rw. Proc Natl Acad Sci U S A. 2008 Jun 3;105(22):7827-32. doi: 10.1073/pnas.0802866105. Epub 2008 May 29. Proc Natl Acad Sci U S A. 2008. PMID: 18511559 Free PMC article.
Activation of the NF-kappaB pathway by adeno-associated virus (AAV) vectors and its implications in immune response and gene therapy.
Jayandharan GR, Aslanidi G, Martino AT, Jahn SC, Perrin GQ, Herzog RW, Srivastava A. Jayandharan GR, et al. Among authors: herzog rw. Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3743-8. doi: 10.1073/pnas.1012753108. Epub 2011 Feb 14. Proc Natl Acad Sci U S A. 2011. Retraction in: Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):E343. doi: 10.1073/pnas.1720655115 PMID: 21321191 Free PMC article. Retracted.
Superior In vivo Transduction of Human Hepatocytes Using Engineered AAV3 Capsid.
Vercauteren K, Hoffman BE, Zolotukhin I, Keeler GD, Xiao JW, Basner-Tschakarjan E, High KA, Ertl HC, Rice CM, Srivastava A, de Jong YP, Herzog RW. Vercauteren K, et al. Among authors: herzog rw. Mol Ther. 2016 Jun;24(6):1042-1049. doi: 10.1038/mt.2016.61. Epub 2016 Mar 29. Mol Ther. 2016. PMID: 27019999 Free PMC article.
Immune Responses to Viral Gene Therapy Vectors.
Shirley JL, de Jong YP, Terhorst C, Herzog RW. Shirley JL, et al. Among authors: herzog rw. Mol Ther. 2020 Mar 4;28(3):709-722. doi: 10.1016/j.ymthe.2020.01.001. Epub 2020 Jan 10. Mol Ther. 2020. PMID: 31968213 Free PMC article. Review.
Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice.
Zou C, Vercauteren KOA, Michailidis E, Kabbani M, Zoluthkin I, Quirk C, Chiriboga L, Yazicioglu M, Anguela XM, Meuleman P, High KA, Herzog RW, de Jong YP. Zou C, et al. Among authors: herzog rw. Mol Ther Methods Clin Dev. 2020 Jun 2;18:189-198. doi: 10.1016/j.omtm.2020.05.033. eCollection 2020 Sep 11. Mol Ther Methods Clin Dev. 2020. PMID: 32637450 Free PMC article.
Engineering and In Vitro Selection of a Novel AAV3B Variant with High Hepatocyte Tropism and Reduced Seroreactivity.
Biswas M, Marsic D, Li N, Zou C, Gonzalez-Aseguinolaza G, Zolotukhin I, Kumar SRP, Rana J, Butterfield JSS, Kondratov O, de Jong YP, Herzog RW, Zolotukhin S. Biswas M, et al. Among authors: herzog rw. Mol Ther Methods Clin Dev. 2020 Oct 4;19:347-361. doi: 10.1016/j.omtm.2020.09.019. eCollection 2020 Dec 11. Mol Ther Methods Clin Dev. 2020. PMID: 33145371 Free PMC article.
Liver gene therapy and hepatocellular carcinoma: A complex web.
de Jong YP, Herzog RW. de Jong YP, et al. Among authors: herzog rw. Mol Ther. 2021 Apr 7;29(4):1353-1354. doi: 10.1016/j.ymthe.2021.03.009. Epub 2021 Mar 19. Mol Ther. 2021. PMID: 33743193 Free PMC article. No abstract available.
250 results