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Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study.
Chughlay MF, El Gaaloul M, Donini C, Campo B, Berghmans PJ, Lucardie A, Marx MW, Cherkaoui-Rbati MH, Langdon G, Angulo-Barturen I, Viera S, Rosanas-Urgell A, Van Geertruyden JP, Chalon S. Chughlay MF, et al. Am J Trop Med Hyg. 2021 Feb 8;104(4):1348-1358. doi: 10.4269/ajtmh.20-1165. Am J Trop Med Hyg. 2021. PMID: 33556040 Free PMC article.
Concentration-QT modelling of the novel DHFR inhibitor P218 in healthy male volunteers.
Täubel J, Lorch U, Ferber G, Spencer CS, Freier A, Coates S, El Gaaloul M, Donini C, Chughlay MF, Chalon S. Täubel J, et al. Among authors: chughlay mf. Br J Clin Pharmacol. 2022 Jan;88(1):128-137. doi: 10.1111/bcp.14933. Epub 2021 Jul 9. Br J Clin Pharmacol. 2022. PMID: 34075612 Free PMC article. Clinical Trial.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Coadministered Ruxolitinib and Artemether-Lumefantrine in Healthy Adults.
Chughlay MF, Barnes KI, El Gaaloul M, Abla N, Möhrle JJ, Griffin P, van Giersbergen P, Reuter SE, Schultz HB, Kress A, Tapley P, Webster RA, Wells T, McCarthy JS, Barber BE, Marquart L, Boyle MJ, Engwerda CR, Chalon S. Chughlay MF, et al. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0158421. doi: 10.1128/AAC.01584-21. Epub 2021 Oct 25. Antimicrob Agents Chemother. 2022. PMID: 34694880 Free PMC article. Clinical Trial.
Safety, Tolerability, and Parasite Clearance Kinetics in Controlled Human Malaria Infection after Direct Venous Inoculation of Plasmodium falciparum Sporozoites: A Model for Evaluating New Blood-Stage Antimalarial Drugs.
Chughlay MF, Chalon S, El Gaaloul M, Gobeau N, Möhrle JJ, Berghmans PJ, Van Leuven K, Marx MW, Rosanas-Urgell A, Flynn J, Escoffier E, Izquierdo-Juncàs D, Jansen B, Mitov V, Kümmel A, Van Geertruyden JP, Barnes KI. Chughlay MF, et al. Am J Trop Med Hyg. 2022 Aug 29;107(4):804-814. doi: 10.4269/ajtmh.21-1297. Print 2022 Oct 12. Am J Trop Med Hyg. 2022. PMID: 36037868 Free PMC article. Clinical Trial.
13 results