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First-in-human clinical trial to assess the safety, tolerability and pharmacokinetics of P218, a novel candidate for malaria chemoprotection.
Chughlay MF, Rossignol E, Donini C, El Gaaloul M, Lorch U, Coates S, Langdon G, Hammond T, Möhrle J, Chalon S. Chughlay MF, et al. Among authors: donini c. Br J Clin Pharmacol. 2020 Jun;86(6):1113-1124. doi: 10.1111/bcp.14219. Epub 2020 Feb 12. Br J Clin Pharmacol. 2020. PMID: 31925817 Free PMC article. Clinical Trial.
Safety, Tolerability, Pharmacokinetics, and Antimalarial Activity of the Novel Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048 in Healthy Volunteers.
Sinxadi P, Donini C, Johnstone H, Langdon G, Wiesner L, Allen E, Duparc S, Chalon S, McCarthy JS, Lorch U, Chibale K, Möhrle J, Barnes KI. Sinxadi P, et al. Among authors: donini c. Antimicrob Agents Chemother. 2020 Mar 24;64(4):e01896-19. doi: 10.1128/AAC.01896-19. Print 2020 Mar 24. Antimicrob Agents Chemother. 2020. PMID: 31932368 Free PMC article. Clinical Trial.
A Phase 1, Placebo-controlled, Randomized, Single Ascending Dose Study and a Volunteer Infection Study to Characterize the Safety, Pharmacokinetics, and Antimalarial Activity of the Plasmodium Phosphatidylinositol 4-Kinase Inhibitor MMV390048.
McCarthy JS, Donini C, Chalon S, Woodford J, Marquart L, Collins KA, Rozenberg FD, Fidock DA, Cherkaoui-Rbati MH, Gobeau N, Möhrle JJ. McCarthy JS, et al. Among authors: donini c. Clin Infect Dis. 2020 Dec 17;71(10):e657-e664. doi: 10.1093/cid/ciaa368. Clin Infect Dis. 2020. PMID: 32239164 Free PMC article. Clinical Trial.
Chemoprotective Antimalarial Activity of P218 against Plasmodium falciparum: A Randomized, Placebo-Controlled Volunteer Infection Study.
Chughlay MF, El Gaaloul M, Donini C, Campo B, Berghmans PJ, Lucardie A, Marx MW, Cherkaoui-Rbati MH, Langdon G, Angulo-Barturen I, Viera S, Rosanas-Urgell A, Van Geertruyden JP, Chalon S. Chughlay MF, et al. Among authors: donini c. Am J Trop Med Hyg. 2021 Feb 8;104(4):1348-1358. doi: 10.4269/ajtmh.20-1165. Am J Trop Med Hyg. 2021. PMID: 33556040 Free PMC article.
Concentration-QT modelling of the novel DHFR inhibitor P218 in healthy male volunteers.
Täubel J, Lorch U, Ferber G, Spencer CS, Freier A, Coates S, El Gaaloul M, Donini C, Chughlay MF, Chalon S. Täubel J, et al. Among authors: donini c. Br J Clin Pharmacol. 2022 Jan;88(1):128-137. doi: 10.1111/bcp.14933. Epub 2021 Jul 9. Br J Clin Pharmacol. 2022. PMID: 34075612 Free PMC article. Clinical Trial.
Monoclonal Antibodies for Malaria.
Wells T, Donini C. Wells T, et al. Among authors: donini c. N Engl J Med. 2022 Aug 4;387(5):462-465. doi: 10.1056/NEJMe2208131. N Engl J Med. 2022. PMID: 35921457 No abstract available.
Malaria - Epidemiology, Treatment, and Prevention.
Baden L, Catteruccia F, Diabaté A, Donini C, Nosten F, O'Neill S, Osier F, Phyo AP, White N. Baden L, et al. Among authors: donini c. N Engl J Med. 2023 Feb 2;388(5):e9. doi: 10.1056/NEJMp2216703. N Engl J Med. 2023. PMID: 36724327 No abstract available.
ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria.
Miley GP, Pou S, Winter R, Nilsen A, Li Y, Kelly JX, Stickles AM, Mather MW, Forquer IP, Pershing AM, White K, Shackleford D, Saunders J, Chen G, Ting LM, Kim K, Zakharov LN, Donini C, Burrows JN, Vaidya AB, Charman SA, Riscoe MK. Miley GP, et al. Among authors: donini c. Antimicrob Agents Chemother. 2015 Sep;59(9):5555-60. doi: 10.1128/AAC.01183-15. Epub 2015 Jun 29. Antimicrob Agents Chemother. 2015. PMID: 26124159 Free PMC article.
48 results