Yang T - Search Results

1

Deep Mutational Scan of an SCN5A Voltage Sensor.

Glazer AM, Kroncke BM, Matreyek KA, Yang T, Wada Y, Shields T, Salem JE, Fowler DM, Roden DM. Glazer AM, et al. Among authors: yang t. Circ Genom Precis Med. 2020 Feb;13(1):e002786. doi: 10.1161/CIRCGEN.119.002786. Epub 2020 Jan 12. Circ Genom Precis Med. 2020. PMID: 31928070 Free PMC article.

2

SCN5A variant R222Q generated abnormal changes in cardiac sodium current and action potentials in murine myocytes and Purkinje cells.

Daniel LL, Yang T, Kroncke B, Hall L, Stroud D, Roden DM. Daniel LL, et al. Among authors: yang t. Heart Rhythm. 2019 Nov;16(11):1676-1685. doi: 10.1016/j.hrthm.2019.05.017. Epub 2019 May 21. Heart Rhythm. 2019. PMID: 31125670 Free PMC article.

3

Phosphorylation of the IKs channel complex inhibits drug block: novel mechanism underlying variable antiarrhythmic drug actions.

Yang T, Kanki H, Roden DM. Yang T, et al. Circulation. 2003 Jul 15;108(2):132-4. doi: 10.1161/01.CIR.0000082708.86266.B8. Epub 2003 Jun 30. Circulation. 2003. PMID: 12835205

4

Unmasking of brugada syndrome by lithium.

Darbar D, Yang T, Churchwell K, Wilde AA, Roden DM. Darbar D, et al. Among authors: yang t. Circulation. 2005 Sep 13;112(11):1527-31. doi: 10.1161/CIRCULATIONAHA.105.548487. Epub 2005 Sep 6. Circulation. 2005. PMID: 16144991 Free PMC article.

5

New mechanism contributing to drug-induced arrhythmia: rescue of a misprocessed LQT3 mutant.

Liu K, Yang T, Viswanathan PC, Roden DM. Liu K, et al. Among authors: yang t. Circulation. 2005 Nov 22;112(21):3239-46. doi: 10.1161/CIRCULATIONAHA.105.564008. Circulation. 2005. PMID: 16301357

6

Voltage-gated sodium channels are required for heart development in zebrafish.

Chopra SS, Stroud DM, Watanabe H, Bennett JS, Burns CG, Wells KS, Yang T, Zhong TP, Roden DM. Chopra SS, et al. Among authors: yang t. Circ Res. 2010 Apr 30;106(8):1342-50. doi: 10.1161/CIRCRESAHA.109.213132. Epub 2010 Mar 25. Circ Res. 2010. PMID: 20339120 Free PMC article.

7

Informatic and functional approaches to identifying a regulatory region for the cardiac sodium channel.

Atack TC, Stroud DM, Watanabe H, Yang T, Hall L, Hipkens SB, Lowe JS, Leake B, Magnuson MA, Yang P, Roden DM. Atack TC, et al. Among authors: yang t, yang p. Circ Res. 2011 Jun 24;109(1):38-46. doi: 10.1161/CIRCRESAHA.110.235630. Epub 2011 May 12. Circ Res. 2011. PMID: 21566215 Free PMC article.

8

Striking In vivo phenotype of a disease-associated human SCN5A mutation producing minimal changes in vitro.

Watanabe H, Yang T, Stroud DM, Lowe JS, Harris L, Atack TC, Wang DW, Hipkens SB, Leake B, Hall L, Kupershmidt S, Chopra N, Magnuson MA, Tanabe N, Knollmann BC, George AL Jr, Roden DM. Watanabe H, et al. Among authors: yang t. Circulation. 2011 Aug 30;124(9):1001-11. doi: 10.1161/CIRCULATIONAHA.110.987248. Epub 2011 Aug 8. Circulation. 2011. PMID: 21824921 Free PMC article.

9

Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic.

Yang T, Atack TC, Stroud DM, Zhang W, Hall L, Roden DM. Yang T, et al. Circ Res. 2012 Jul 20;111(3):322-32. doi: 10.1161/CIRCRESAHA.112.265173. Epub 2012 Jun 20. Circ Res. 2012. PMID: 22723299 Free PMC article.

10

Screening for acute IKr block is insufficient to detect torsades de pointes liability: role of late sodium current.

Yang T, Chun YW, Stroud DM, Mosley JD, Knollmann BC, Hong C, Roden DM. Yang T, et al. Circulation. 2014 Jul 15;130(3):224-34. doi: 10.1161/CIRCULATIONAHA.113.007765. Epub 2014 Jun 3. Circulation. 2014. PMID: 24895457 Free PMC article.

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