Cao M - Search Results

1

Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.

Swope N, Chung WK, Cao M, Motabar D, Liu D, Ahuja S, Handlogten M. Swope N, et al. Among authors: cao m. Biotechnol Bioeng. 2020 Apr;117(4):1063-1071. doi: 10.1002/bit.27264. Epub 2020 Jan 23. Biotechnol Bioeng. 2020. PMID: 31930476 Free PMC article.

2

Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability.

Chung WK, Russell B, Yang Y, Handlogten M, Hudak S, Cao M, Wang J, Robbins D, Ahuja S, Zhu M. Chung WK, et al. Among authors: cao m. Biotechnol Bioeng. 2017 Jun;114(6):1264-1274. doi: 10.1002/bit.26265. Epub 2017 Mar 6. Biotechnol Bioeng. 2017. PMID: 28186329 Free PMC article.

3

Characterization and analysis of scFv-IgG bispecific antibody size variants.

Cao M, Wang C, Chung WK, Motabar D, Wang J, Christian E, Lin S, Hunter A, Wang X, Liu D. Cao M, et al. MAbs. 2018 Nov-Dec;10(8):1236-1247. doi: 10.1080/19420862.2018.1505398. Epub 2018 Sep 20. MAbs. 2018. PMID: 30130449 Free PMC article.

4

A systematic approach for analysis and characterization of mispairing in bispecific antibodies with asymmetric architecture.

Wang C, Vemulapalli B, Cao M, Gadre D, Wang J, Hunter A, Wang X, Liu D. Wang C, et al. Among authors: cao m. MAbs. 2018 Nov-Dec;10(8):1226-1235. doi: 10.1080/19420862.2018.1511198. Epub 2018 Sep 20. MAbs. 2018. PMID: 30153083 Free PMC article.

5

Cathepsin L Causes Proteolytic Cleavage of Chinese-Hamster-Ovary Cell Expressed Proteins During Processing and Storage: Identification, Characterization, and Mitigation.

Luo H, Tie L, Cao M, Hunter AK, Pabst TM, Du J, Field R, Li Y, Wang WK. Luo H, et al. Among authors: cao m. Biotechnol Prog. 2019 Jan;35(1):e2732. doi: 10.1002/btpr.2732. Epub 2018 Nov 4. Biotechnol Prog. 2019. PMID: 30320962 Free PMC article.

6

Characterization and quantification of succinimide using peptide mapping under low-pH conditions and hydrophobic interaction chromatography.

Cao M, Mulagapati SHR, Vemulapalli B, Wang J, Saveliev SV, Urh M, Hunter A, Liu D. Cao M, et al. Anal Biochem. 2019 Feb 1;566:151-159. doi: 10.1016/j.ab.2018.11.021. Epub 2018 Nov 29. Anal Biochem. 2019. PMID: 30503708 Free article.

7

Charge variants characterization and release assay development for co-formulated antibodies as a combination therapy.

Cao M, De Mel N, Shannon A, Prophet M, Wang C, Xu W, Niu B, Kim J, Albarghouthi M, Liu D, Meinke E, Lin S, Wang X, Wang J. Cao M, et al. MAbs. 2019 Apr;11(3):489-499. doi: 10.1080/19420862.2019.1578137. Epub 2019 Feb 20. MAbs. 2019. PMID: 30786796 Free PMC article.

8

A method to directly analyze free-drug-related species in antibody-drug conjugates without sample preparation.

de Mel N, Mulagapati SHR, Cao M, Liu D. de Mel N, et al. Among authors: cao m. J Chromatogr B Analyt Technol Biomed Life Sci. 2019 May 15;1116:51-59. doi: 10.1016/j.jchromb.2019.04.012. Epub 2019 Apr 5. J Chromatogr B Analyt Technol Biomed Life Sci. 2019. PMID: 30981182

9

Site-specific antibody-drug conjugate heterogeneity characterization and heterogeneity root cause analysis.

Cao M, De Mel N, Jiao Y, Howard J, Parthemore C, Korman S, Thompson C, Wendeler M, Liu D. Cao M, et al. MAbs. 2019 Aug/Sep;11(6):1064-1076. doi: 10.1080/19420862.2019.1624127. Epub 2019 Jun 14. MAbs. 2019. PMID: 31198090 Free PMC article.

10

An Automated and Qualified Platform Method for Site-Specific Succinimide and Deamidation Quantitation Using Low-pH Peptide Mapping.

Cao M, Xu W, Niu B, Kabundi I, Luo H, Prophet M, Chen W, Liu D, Saveliev SV, Urh M, Wang J. Cao M, et al. J Pharm Sci. 2019 Nov;108(11):3540-3549. doi: 10.1016/j.xphs.2019.07.019. Epub 2019 Jul 30. J Pharm Sci. 2019. PMID: 31374319 Free article.

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