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Discovery of a Brain-Penetrant ATP-Competitive Inhibitor of the Mechanistic Target of Rapamycin (mTOR) for CNS Disorders.
Bonazzi S, Goold CP, Gray A, Thomsen NM, Nunez J, Karki RG, Gorde A, Biag JD, Malik HA, Sun Y, Liang G, Lubicka D, Salas S, Labbe-Giguere N, Keaney EP, McTighe S, Liu S, Deng L, Piizzi G, Lombardo F, Burdette D, Dodart JC, Wilson CJ, Peukert S, Curtis D, Hamann LG, Murphy LO. Bonazzi S, et al. Among authors: mctighe s. J Med Chem. 2020 Feb 13;63(3):1068-1083. doi: 10.1021/acs.jmedchem.9b01398. Epub 2020 Jan 31. J Med Chem. 2020. PMID: 31955578
Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes.
Bonazzi S, Gray A, Thomsen NM, Biag J, Labbe-Giguere N, Keaney EP, Malik HA, Sun Y, Nunez J, Karki RG, Knapp M, Elling R, Fuller J, Pardee G, Craig L, Capre K, Salas S, Gorde A, Liang G, Lubicka D, McTighe SM, Goold C, Liu S, Deng L, Hong J, Fekete A, Stadelmann P, Frieauff W, Elhajouji A, Bauer D, Lerchner A, Radetich B, Furet P, Piizzi G, Burdette D, Wilson CJ, Peukert S, Hamann LG, Murphy LO, Curtis D. Bonazzi S, et al. Among authors: mctighe sm. J Med Chem. 2023 Jul 13;66(13):9095-9119. doi: 10.1021/acs.jmedchem.3c00705. Epub 2023 Jul 3. J Med Chem. 2023. PMID: 37399505
Seizure reduction in TSC2-mutant mouse model by an mTOR catalytic inhibitor.
Dhamne SC, Modi ME, Gray A, Bonazzi S, Craig L, Bainbridge E, Lalani L, Super CE, Schaeffer S, Capre K, Lubicka D, Liang G, Burdette D, McTighe SM, Gurnani S, Vermudez SAD, Curtis D, Wilson CJ, Hameed MQ, D'Amore A, Rotenberg A, Sahin M. Dhamne SC, et al. Among authors: mctighe sm. Ann Clin Transl Neurol. 2023 Oct;10(10):1790-1801. doi: 10.1002/acn3.51868. Epub 2023 Aug 6. Ann Clin Transl Neurol. 2023. PMID: 37545094 Free PMC article.
Discovery and characterization of novel TRPML1 agonists.
Peng X, Holler CJ, Alves AF, Oliviera MG, Speake M, Pugliese A, Oskouei MR, de Freitas ID, Chen AY, Gallegos R, McTighe SM, Koenig G, Hurst RS, Blain JF, Lanter JC, Burnett DA. Peng X, et al. Among authors: mctighe sm. Bioorg Med Chem Lett. 2024 Jan 15;98:129595. doi: 10.1016/j.bmcl.2023.129595. Epub 2023 Dec 22. Bioorg Med Chem Lett. 2024. PMID: 38141860
A nodule on the tip of the finger.
McTighe S, Stanley M, Lindstrom J. McTighe S, et al. Pediatr Dermatol. 2023 Jan;40(1):195-197. doi: 10.1111/pde.15093. Pediatr Dermatol. 2023. PMID: 36670502 No abstract available.
Cryopreservation of Anopheles stephensi embryos.
James ER, Wen Y, Overby J, Pluchino K, McTighe S, Matheny S, Eappen A, Hoffman SL, Billingsley PF. James ER, et al. Among authors: mctighe s. Sci Rep. 2022 Jan 7;12(1):43. doi: 10.1038/s41598-021-04113-x. Sci Rep. 2022. PMID: 34997079 Free PMC article.
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