Ahuja S - Search Results

1

Online control of cell culture redox potential prevents antibody interchain disulfide bond reduction.

Handlogten MW, Wang J, Ahuja S. Handlogten MW, et al. Among authors: ahuja s. Biotechnol Bioeng. 2020 May;117(5):1329-1336. doi: 10.1002/bit.27281. Epub 2020 Jan 29. Biotechnol Bioeng. 2020. PMID: 31956991

2

Kinetic modeling as a tool to understand the influence of cell culture process parameters on the glycation of monoclonal antibody biotherapeutics.

Agarwal N, Mason A, Pradhan R, Kemper J, Bosley A, Serfiotis-Mitsa D, Wang J, Lindo V, Ahuja S, Hatton D, Savery J, Miro-Quesada G. Agarwal N, et al. Among authors: ahuja s. Biotechnol Prog. 2019 Sep;35(5):e2865. doi: 10.1002/btpr.2865. Epub 2019 Jun 21. Biotechnol Prog. 2019. PMID: 31180183

3

Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability.

Chung WK, Russell B, Yang Y, Handlogten M, Hudak S, Cao M, Wang J, Robbins D, Ahuja S, Zhu M. Chung WK, et al. Among authors: ahuja s. Biotechnol Bioeng. 2017 Jun;114(6):1264-1274. doi: 10.1002/bit.26265. Epub 2017 Mar 6. Biotechnol Bioeng. 2017. PMID: 28186329 Free PMC article.

4

Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing.

Handlogten MW, Zhu M, Ahuja S. Handlogten MW, et al. Among authors: ahuja s. Biotechnol Bioeng. 2017 Jul;114(7):1469-1477. doi: 10.1002/bit.26278. Epub 2017 Mar 20. Biotechnol Bioeng. 2017. PMID: 28262915

5

Intracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO cell process.

Handlogten MW, Lee-O'Brien A, Roy G, Levitskaya SV, Venkat R, Singh S, Ahuja S. Handlogten MW, et al. Among authors: ahuja s. Biotechnol Bioeng. 2018 Jan;115(1):126-138. doi: 10.1002/bit.26460. Biotechnol Bioeng. 2018. PMID: 28941283

6

Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.

Swope N, Chung WK, Cao M, Motabar D, Liu D, Ahuja S, Handlogten M. Swope N, et al. Among authors: ahuja s. Biotechnol Bioeng. 2020 Apr;117(4):1063-1071. doi: 10.1002/bit.27264. Epub 2020 Jan 23. Biotechnol Bioeng. 2020. PMID: 31930476 Free PMC article.

7

Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region.

Handlogten MW, Peng L, Christian EA, Xu W, Lin S, Venkat R, Dall'Acqua W, Ahuja S. Handlogten MW, et al. Among authors: ahuja s. MAbs. 2020 Jan-Dec;12(1):1779974. doi: 10.1080/19420862.2020.1779974. MAbs. 2020. PMID: 32633193 Free PMC article.

8

Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells.

Sinharoy P, Aziz AH, Majewska NI, Ahuja S, Handlogten MW. Sinharoy P, et al. Among authors: ahuja s. Sci Rep. 2020 Oct 6;10(1):16620. doi: 10.1038/s41598-020-73573-4. Sci Rep. 2020. PMID: 33024175 Free PMC article.

9

Development of a high yielding expression platform for the introduction of non-natural amino acids in protein sequences.

Roy G, Reier J, Garcia A, Martin T, Rice M, Wang J, Prophet M, Christie R, Dall'Acqua W, Ahuja S, Bowen MA, Marelli M. Roy G, et al. Among authors: ahuja s. MAbs. 2020 Jan-Dec;12(1):1684749. doi: 10.1080/19420862.2019.1684749. MAbs. 2020. PMID: 31775561 Free PMC article.

10

Application of multivariate analysis and mass transfer principles for refinement of a 3-L bioreactor scale-down model--when shake flasks mimic 15,000-L bioreactors better.

Ahuja S, Jain S, Ram K. Ahuja S, et al. Biotechnol Prog. 2015 Sep-Oct;31(5):1370-80. doi: 10.1002/btpr.2134. Epub 2015 Jul 15. Biotechnol Prog. 2015. PMID: 26097232

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