Durden DL - Search Results

1

Macrophage Syk-PI3Kγ Inhibits Antitumor Immunity: SRX3207, a Novel Dual Syk-PI3K Inhibitory Chemotype Relieves Tumor Immunosuppression.

Joshi S, Liu KX, Zulcic M, Singh AR, Skola D, Glass CK, Sanders PD, Sharabi AB, Pham TV, Tamayo P, Shiang D, Dinh HQ, Hedrick CC, Morales GA, Garlich JR, Durden DL. Joshi S, et al. Among authors: durden dl. Mol Cancer Ther. 2020 Mar;19(3):755-764. doi: 10.1158/1535-7163.MCT-19-0947. Epub 2020 Jan 23. Mol Cancer Ther. 2020. PMID: 31974273 Free PMC article.

2

A macrophage-dominant PI3K isoform controls hypoxia-induced HIF1α and HIF2α stability and tumor growth, angiogenesis, and metastasis.

Joshi S, Singh AR, Zulcic M, Durden DL. Joshi S, et al. Among authors: durden dl. Mol Cancer Res. 2014 Oct;12(10):1520-31. doi: 10.1158/1541-7786.MCR-13-0682. Epub 2014 Aug 7. Mol Cancer Res. 2014. PMID: 25103499

3

Pan-PI-3 kinase inhibitor SF1126 shows antitumor and antiangiogenic activity in renal cell carcinoma.

Joshi S, Singh AR, Durden DL. Joshi S, et al. Among authors: durden dl. Cancer Chemother Pharmacol. 2015 Mar;75(3):595-608. doi: 10.1007/s00280-014-2639-x. Epub 2015 Jan 13. Cancer Chemother Pharmacol. 2015. PMID: 25578041

4

Single Agent and Synergistic Activity of the "First-in-Class" Dual PI3K/BRD4 Inhibitor SF1126 with Sorafenib in Hepatocellular Carcinoma.

Singh AR, Joshi S, Burgoyne AM, Sicklick JK, Ikeda S, Kono Y, Garlich JR, Morales GA, Durden DL. Singh AR, et al. Among authors: durden dl. Mol Cancer Ther. 2016 Nov;15(11):2553-2562. doi: 10.1158/1535-7163.MCT-15-0976. Epub 2016 Aug 5. Mol Cancer Ther. 2016. PMID: 27496136 Free PMC article.

5

Dual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis.

Andrews FH, Singh AR, Joshi S, Smith CA, Morales GA, Garlich JR, Durden DL, Kutateladze TG. Andrews FH, et al. Among authors: durden dl. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1072-E1080. doi: 10.1073/pnas.1613091114. Epub 2017 Jan 30. Proc Natl Acad Sci U S A. 2017. PMID: 28137841 Free PMC article.

6

SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer.

Joshi S, Singh AR, Liu KX, Pham TV, Zulcic M, Skola D, Chun HB, Glass CK, Morales GA, Garlich JR, Durden DL. Joshi S, et al. Among authors: durden dl. Mol Cancer Ther. 2019 Jun;18(6):1036-1044. doi: 10.1158/1535-7163.MCT-18-1206. Epub 2019 Apr 24. Mol Cancer Ther. 2019. PMID: 31018997 Free PMC article.

7

Rac2 controls tumor growth, metastasis and M1-M2 macrophage differentiation in vivo.

Joshi S, Singh AR, Zulcic M, Bao L, Messer K, Ideker T, Dutkowski J, Durden DL. Joshi S, et al. Among authors: durden dl. PLoS One. 2014 Apr 25;9(4):e95893. doi: 10.1371/journal.pone.0095893. eCollection 2014. PLoS One. 2014. PMID: 24770346 Free PMC article.

8

PTEN and PI-3 kinase inhibitors control LPS signaling and the lymphoproliferative response in the CD19+ B cell compartment.

Singh AR, Peirce SK, Joshi S, Durden DL. Singh AR, et al. Among authors: durden dl. Exp Cell Res. 2014 Sep 10;327(1):78-90. doi: 10.1016/j.yexcr.2014.05.016. Epub 2014 May 29. Exp Cell Res. 2014. PMID: 24881819

9

MDM2 regulates hypoxic hypoxia-inducible factor 1α stability in an E3 ligase, proteasome, and PTEN-phosphatidylinositol 3-kinase-AKT-dependent manner.

Joshi S, Singh AR, Durden DL. Joshi S, et al. Among authors: durden dl. J Biol Chem. 2014 Aug 15;289(33):22785-22797. doi: 10.1074/jbc.M114.587493. Epub 2014 Jun 30. J Biol Chem. 2014. PMID: 24982421 Free PMC article.

10

Anti-tumor effect of a novel PI3-kinase inhibitor, SF1126, in (12) V-Ha-Ras transgenic mouse glioma model.

Singh AR, Joshi S, George E, Durden DL. Singh AR, et al. Among authors: durden dl. Cancer Cell Int. 2014 Nov 12;14(1):105. doi: 10.1186/s12935-014-0105-9. eCollection 2014. Cancer Cell Int. 2014. PMID: 25425962 Free PMC article.

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