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ErbB2 overexpression in human breast carcinoma is correlated with p21Cip1 up-regulation and tyrosine-15 hyperphosphorylation of p34Cdc2: poor responsiveness to chemotherapy with cyclophoshamide methotrexate, and 5-fluorouracil is associated with Erb2 overexpression and with p21Cip1 overexpression.
Yang W, Klos KS, Zhou X, Yao J, Yang Y, Smith TL, Shi D, Yu D. Yang W, et al. Among authors: zhou x. Cancer. 2003 Sep 15;98(6):1123-30. doi: 10.1002/cncr.11625. Cancer. 2003. PMID: 12973835 Free article.
ErbB2 increases vascular endothelial growth factor protein synthesis via activation of mammalian target of rapamycin/p70S6K leading to increased angiogenesis and spontaneous metastasis of human breast cancer cells.
Klos KS, Wyszomierski SL, Sun M, Tan M, Zhou X, Li P, Yang W, Yin G, Hittelman WN, Yu D. Klos KS, et al. Among authors: zhou x. Cancer Res. 2006 Feb 15;66(4):2028-37. doi: 10.1158/0008-5472.CAN-04-4559. Cancer Res. 2006. PMID: 16489002 Free article.
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