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Page 1
Identification and prioritization of myeloid malignancy germline variants in a large cohort of adult patients with AML.
Yang F, Long N, Anekpuritanang T, Bottomly D, Savage JC, Lee T, Solis-Ruiz J, Borate U, Wilmot B, Tognon C, Bock AM, Pollyea DA, Radhakrishnan S, Radhakrishnan S, Patel P, Collins RH, Tantravahi S, Deininger MW, Fan G, Druker B, Shinde U, Tyner JW, Press RD, McWeeney S, Agarwal A. Yang F, et al. Among authors: savage jc. Blood. 2022 Feb 24;139(8):1208-1221. doi: 10.1182/blood.2021011354. Blood. 2022. PMID: 34482403 Free PMC article. Clinical Trial.
Dark Microglia Are Abundant in Normal Postnatal Development, where they Remodel Synapses via Phagocytosis and Trogocytosis, and Are Dependent on TREM2.
Vecchiarelli HA, Bisht K, Sharma K, Weiser Novak S, Traetta ME, Garcia-Segura ME, St-Pierre MK, Savage JC, Willis C, Picard K, Bordeleau M, Vernoux N, Khakpour M, Garg R, Loewen SM, Murray CJ, Grinberg YY, Faustino J, Halvorson T, Lau V, Pluchino S, Vexler ZS, Carson MJ, Manor U, Peruzzotti-Jametti L, Tremblay MÈ. Vecchiarelli HA, et al. Among authors: savage jc. bioRxiv [Preprint]. 2024 Oct 18:2024.10.15.618087. doi: 10.1101/2024.10.15.618087. bioRxiv. 2024. PMID: 39463930 Free PMC article. Preprint.
Bone marrow-derived myeloid cells transiently colonize the brain during postnatal development and interact with glutamatergic synapses.
Carrier M, Robert MÈ, St-Pierre MK, Ibáñez FG, Gonçalves de Andrade E, Laroche A, Picard K, Vecchiarelli HA, Savage JC, Boilard É, Desjardins M, Tremblay MÈ. Carrier M, et al. Among authors: savage jc. iScience. 2024 May 21;27(7):110037. doi: 10.1016/j.isci.2024.110037. eCollection 2024 Jul 19. iScience. 2024. PMID: 39021809 Free PMC article.
Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses.
Bolton JL, Short AK, Othy S, Kooiker CL, Shao M, Gunn BG, Beck J, Bai X, Law SM, Savage JC, Lambert JJ, Belelli D, Tremblay MÈ, Cahalan MD, Baram TZ. Bolton JL, et al. Among authors: savage jc. Cell Rep. 2022 Mar 29;38(13):110600. doi: 10.1016/j.celrep.2022.110600. Cell Rep. 2022. PMID: 35354026 Free PMC article.
Maternal high-fat diet modifies myelin organization, microglial interactions, and results in social memory and sensorimotor gating deficits in adolescent mouse offspring.
Bordeleau M, Fernández de Cossío L, Lacabanne C, Savage JC, Vernoux N, Chakravarty M, Tremblay MÈ. Bordeleau M, et al. Among authors: savage jc. Brain Behav Immun Health. 2021 Jun 9;15:100281. doi: 10.1016/j.bbih.2021.100281. eCollection 2021 Aug. Brain Behav Immun Health. 2021. PMID: 34589781 Free PMC article.
47 results