Wen WY - Search Results

1

BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma.

Li JT, Yin M, Wang D, Wang J, Lei MZ, Zhang Y, Liu Y, Zhang L, Zou SW, Hu LP, Zhang ZG, Wang YP, Wen WY, Lu HJ, Chen ZJ, Su D, Lei QY. Li JT, et al. Among authors: wen wy. Nat Cell Biol. 2020 Feb;22(2):167-174. doi: 10.1038/s41556-019-0455-6. Epub 2020 Feb 6. Nat Cell Biol. 2020. PMID: 32029896

2

A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases.

Wang Z, Liu Z, Chen X, Li J, Yao W, Huang S, Gu A, Lei QY, Mao Y, Wen W. Wang Z, et al. Nat Commun. 2019 Jul 18;10(1):3162. doi: 10.1038/s41467-019-11224-7. Nat Commun. 2019. PMID: 31320636 Free PMC article.

3

Arginine methylation of ribose-5-phosphate isomerase A senses glucose to promote human colorectal cancer cell survival.

Guo J, Zhang Q, Su Y, Lu X, Wang Y, Yin M, Hu W, Wen W, Lei QY. Guo J, et al. Sci China Life Sci. 2020 Sep;63(9):1394-1405. doi: 10.1007/s11427-019-1562-y. Epub 2020 Mar 6. Sci China Life Sci. 2020. PMID: 32157557

4

Par complex cluster formation mediated by phase separation.

Liu Z, Yang Y, Gu A, Xu J, Mao Y, Lu H, Hu W, Lei QY, Li Z, Zhang M, Cai Y, Wen W. Liu Z, et al. Nat Commun. 2020 May 8;11(1):2266. doi: 10.1038/s41467-020-16135-6. Nat Commun. 2020. PMID: 32385244 Free PMC article.

5

FOXM1D potentiates PKM2-mediated tumor glycolysis and angiogenesis.

Zhang W, Zhang X, Huang S, Chen J, Ding P, Wang Q, Li L, Lv X, Li L, Zhang P, Zhou D, Wen W, Wang Y, Lei QY, Wu J, Hu W. Zhang W, et al. Mol Oncol. 2021 May;15(5):1466-1485. doi: 10.1002/1878-0261.12879. Epub 2021 Apr 2. Mol Oncol. 2021. PMID: 33314660 Free PMC article.

6

Palmitoylation of MDH2 by ZDHHC18 activates mitochondrial respiration and accelerates ovarian cancer growth.

Pei X, Li KY, Shen Y, Li JT, Lei MZ, Fang CY, Lu HJ, Yang HJ, Wen W, Yin M, Qu J, Lei QY. Pei X, et al. Sci China Life Sci. 2022 Oct;65(10):2017-2030. doi: 10.1007/s11427-021-2048-2. Epub 2022 Mar 25. Sci China Life Sci. 2022. PMID: 35366151

7

Diet high in branched-chain amino acid promotes PDAC development by USP1-mediated BCAT2 stabilization.

Li JT, Li KY, Su Y, Shen Y, Lei MZ, Zhang F, Yin M, Chen ZJ, Wen WY, Hu WG, Su D, Qu J, Lei QY. Li JT, et al. Among authors: wen wy. Natl Sci Rev. 2021 Nov 26;9(5):nwab212. doi: 10.1093/nsr/nwab212. eCollection 2022 May. Natl Sci Rev. 2021. PMID: 35663242 Free PMC article.

8

Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression.

Qian L, Li N, Lu XC, Xu M, Liu Y, Li K, Zhang Y, Hu K, Qi YT, Yao J, Wu YL, Wen W, Huang S, Chen ZJ, Yin M, Lei QY. Qian L, et al. Nat Metab. 2023 Jul;5(7):1159-1173. doi: 10.1038/s42255-023-00818-7. Epub 2023 Jun 19. Nat Metab. 2023. PMID: 37337119

9

Feedback regulation of ubiquitination and phase separation of HECT E3 ligases.

Li J, Zhu K, Gu A, Zhang Y, Huang S, Hu R, Hu W, Lei QY, Wen W. Li J, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2302478120. doi: 10.1073/pnas.2302478120. Epub 2023 Aug 7. Proc Natl Acad Sci U S A. 2023. PMID: 37549262 Free PMC article.

10

Excessive STAU1 condensate drives mTOR translation and autophagy dysfunction in neurodegeneration.

Zhao R, Huang S, Li J, Gu A, Fu M, Hua W, Mao Y, Lei QY, Lu B, Wen W. Zhao R, et al. J Cell Biol. 2024 Aug 5;223(8):e202311127. doi: 10.1083/jcb.202311127. Epub 2024 Jun 24. J Cell Biol. 2024. PMID: 38913026

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