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Targeting Hepatic Glutaminase 1 Ameliorates Non-alcoholic Steatohepatitis by Restoring Very-Low-Density Lipoprotein Triglyceride Assembly.
Simon J, Nuñez-García M, Fernández-Tussy P, Barbier-Torres L, Fernández-Ramos D, Gómez-Santos B, Buqué X, Lopitz-Otsoa F, Goikoetxea-Usandizaga N, Serrano-Macia M, Rodriguez-Agudo R, Bizkarguenaga M, Zubiete-Franco I, Gutiérrez-de Juan V, Cabrera D, Alonso C, Iruzubieta P, Romero-Gomez M, van Liempd S, Castro A, Nogueiras R, Varela-Rey M, Falcón-Pérez JM, Villa E, Crespo J, Lu SC, Mato JM, Aspichueta P, Delgado TC, Martínez-Chantar ML. Simon J, et al. Among authors: aspichueta p. Cell Metab. 2020 Mar 3;31(3):605-622.e10. doi: 10.1016/j.cmet.2020.01.013. Epub 2020 Feb 21. Cell Metab. 2020. PMID: 32084378 Free PMC article.
[Molecular basis of obesity-related hepatic steatosis].
Buqué X, Aspichueta P, Ochoa B. Buqué X, et al. Among authors: aspichueta p. Rev Esp Enferm Dig. 2008 Sep;100(9):565-78. doi: 10.4321/s1130-01082008000900007. Rev Esp Enferm Dig. 2008. PMID: 19025308 Free article. Spanish.
Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C.
Miquilena-Colina ME, Lima-Cabello E, Sánchez-Campos S, García-Mediavilla MV, Fernández-Bermejo M, Lozano-Rodríguez T, Vargas-Castrillón J, Buqué X, Ochoa B, Aspichueta P, González-Gallego J, García-Monzón C. Miquilena-Colina ME, et al. Among authors: aspichueta p. Gut. 2011 Oct;60(10):1394-402. doi: 10.1136/gut.2010.222844. Epub 2011 Jan 26. Gut. 2011. PMID: 21270117
Hepatoma cells from mice deficient in glycine N-methyltransferase have increased RAS signaling and activation of liver kinase B1.
Martínez-López N, García-Rodríguez JL, Varela-Rey M, Gutiérrez V, Fernández-Ramos D, Beraza N, Aransay AM, Schlangen K, Lozano JJ, Aspichueta P, Luka Z, Wagner C, Evert M, Calvisi DF, Lu SC, Mato JM, Martínez-Chantar ML. Martínez-López N, et al. Among authors: aspichueta p. Gastroenterology. 2012 Sep;143(3):787-798.e13. doi: 10.1053/j.gastro.2012.05.050. Epub 2012 Jun 8. Gastroenterology. 2012. PMID: 22687285 Free PMC article.
Solute carrier family 2 member 1 is involved in the development of nonalcoholic fatty liver disease.
Vazquez-Chantada M, Gonzalez-Lahera A, Martinez-Arranz I, Garcia-Monzon C, Regueiro MM, Garcia-Rodriguez JL, Schlangen KA, Mendibil I, Rodriguez-Ezpeleta N, Lozano JJ, Banasik K, Justesen JM, Joergensen T, Witte DR, Lauritzen T, Hansen T, Pedersen O, Veyrie N, Clement K, Tordjman J, Tran A, Le Marchand-Brustel Y, Buque X, Aspichueta P, Echevarria-Uraga JJ, Martin-Duce A, Caballeria J, Gual P, Castro A, Mato JM, Martinez-Chantar ML, Aransay AM. Vazquez-Chantada M, et al. Among authors: aspichueta p. Hepatology. 2013 Feb;57(2):505-14. doi: 10.1002/hep.26052. Epub 2012 Nov 27. Hepatology. 2013. PMID: 22961556
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