Hirsch AKH - Search Results

1

Rapid Discovery of Aspartyl Protease Inhibitors Using an Anchoring Approach.

Konstantinidou M, Magari F, Sutanto F, Haupenthal J, Jumde VR, Ünver MY, Heine A, Camacho CJ, Hirsch AKH, Klebe G, Dömling A. Konstantinidou M, et al. Among authors: hirsch akh. ChemMedChem. 2020 Apr 20;15(8):680-684. doi: 10.1002/cmdc.202000024. Epub 2020 Mar 18. ChemMedChem. 2020. PMID: 32187447 Free PMC article.

2

Structure-based design of inhibitors of the aspartic protease endothiapepsin by exploiting dynamic combinatorial chemistry.

Mondal M, Radeva N, Köster H, Park A, Potamitis C, Zervou M, Klebe G, Hirsch AK. Mondal M, et al. Angew Chem Int Ed Engl. 2014 Mar 17;53(12):3259-63. doi: 10.1002/anie.201309682. Epub 2014 Feb 14. Angew Chem Int Ed Engl. 2014. PMID: 24532096

3

Dynamic combinatorial chemistry: a tool to facilitate the identification of inhibitors for protein targets.

Mondal M, Hirsch AK. Mondal M, et al. Chem Soc Rev. 2015 Apr 21;44(8):2455-88. doi: 10.1039/c4cs00493k. Chem Soc Rev. 2015. PMID: 25706945 Review.

4

Structure-Based Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.

Hartman AM, Mondal M, Radeva N, Klebe G, Hirsch AK. Hartman AM, et al. Int J Mol Sci. 2015 Aug 14;16(8):19184-94. doi: 10.3390/ijms160819184. Int J Mol Sci. 2015. PMID: 26287174 Free PMC article.

5

Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin: Fragment-Based Drug Design Facilitated by Dynamic Combinatorial Chemistry.

Mondal M, Radeva N, Fanlo-Virgós H, Otto S, Klebe G, Hirsch AK. Mondal M, et al. Angew Chem Int Ed Engl. 2016 Aug 1;55(32):9422-6. doi: 10.1002/anie.201603074. Epub 2016 Jul 12. Angew Chem Int Ed Engl. 2016. PMID: 27400756 Free PMC article.

6

Fragment-Based Drug Design Facilitated by Protein-Templated Click Chemistry: Fragment Linking and Optimization of Inhibitors of the Aspartic Protease Endothiapepsin.

Mondal M, Unver MY, Pal A, Bakker M, Berrier SP, Hirsch AK. Mondal M, et al. Chemistry. 2016 Oct 10;22(42):14826-14830. doi: 10.1002/chem.201603001. Epub 2016 Sep 7. Chemistry. 2016. PMID: 27604032 Free PMC article.

7

Designed Spiroketal Protein Modulation.

Scheepstra M, Andrei SA, Unver MY, Hirsch AKH, Leysen S, Ottmann C, Brunsveld L, Milroy LG. Scheepstra M, et al. Among authors: hirsch akh. Angew Chem Int Ed Engl. 2017 May 8;56(20):5480-5484. doi: 10.1002/anie.201612504. Epub 2017 Apr 13. Angew Chem Int Ed Engl. 2017. PMID: 28407400 Free PMC article.

8

Compounds Interfering with Embryonic Lethal Abnormal Vision (ELAV) Protein-RNA Complexes: An Avenue for Discovering New Drugs.

Nasti R, Rossi D, Amadio M, Pascale A, Unver MY, Hirsch AKH, Collina S. Nasti R, et al. Among authors: hirsch akh. J Med Chem. 2017 Oct 26;60(20):8257-8267. doi: 10.1021/acs.jmedchem.6b01871. Epub 2017 Jun 19. J Med Chem. 2017. PMID: 28587461

9

Dynamic Combinatorial Chemistry to Identify Binders of ThiT, an S-Component of the Energy-Coupling Factor Transporter for Thiamine.

Monjas L, Swier LJYM, Setyawati I, Slotboom DJ, Hirsch AKH. Monjas L, et al. Among authors: hirsch akh. ChemMedChem. 2017 Oct 20;12(20):1693-1696. doi: 10.1002/cmdc.201700440. Epub 2017 Oct 6. ChemMedChem. 2017. PMID: 28960943 Free PMC article.

10

Druggability Assessment of Targets Used in Kinetic Target-Guided Synthesis.

Unver MY, Gierse RM, Ritchie H, Hirsch AKH. Unver MY, et al. Among authors: hirsch akh. J Med Chem. 2018 Nov 8;61(21):9395-9409. doi: 10.1021/acs.jmedchem.8b00266. Epub 2018 Jun 27. J Med Chem. 2018. PMID: 29873484 Review.

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