Mesecar AD - Search Results

1

Structure-Guided Mutagenesis Alters Deubiquitinating Activity and Attenuates Pathogenesis of a Murine Coronavirus.

Deng X, Chen Y, Mielech AM, Hackbart M, Kesely KR, Mettelman RC, O'Brien A, Chapman ME, Mesecar AD, Baker SC. Deng X, et al. Among authors: mesecar ad. J Virol. 2020 May 18;94(11):e01734-19. doi: 10.1128/JVI.01734-19. Print 2020 May 18. J Virol. 2020. PMID: 32188728 Free PMC article.

2

Design and synthesis of peptidomimetic severe acute respiratory syndrome chymotrypsin-like protease inhibitors.

Ghosh AK, Xi K, Ratia K, Santarsiero BD, Fu W, Harcourt BH, Rota PA, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. J Med Chem. 2005 Nov 3;48(22):6767-71. doi: 10.1021/jm050548m. J Med Chem. 2005. PMID: 16250632

3

The papain-like protease of severe acute respiratory syndrome coronavirus has deubiquitinating activity.

Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. Barretto N, et al. Among authors: mesecar ad. J Virol. 2005 Dec;79(24):15189-98. doi: 10.1128/JVI.79.24.15189-15198.2005. J Virol. 2005. PMID: 16306590 Free PMC article.

4

Severe acute respiratory syndrome coronavirus papain-like protease: structure of a viral deubiquitinating enzyme.

Ratia K, Saikatendu KS, Santarsiero BD, Barretto N, Baker SC, Stevens RC, Mesecar AD. Ratia K, et al. Among authors: mesecar ad. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5717-22. doi: 10.1073/pnas.0510851103. Epub 2006 Mar 31. Proc Natl Acad Sci U S A. 2006. PMID: 16581910 Free PMC article.

5

Deubiquitinating activity of the SARS-CoV papain-like protease.

Barretto N, Jukneliene D, Ratia K, Chen Z, Mesecar AD, Baker SC. Barretto N, et al. Among authors: mesecar ad. Adv Exp Med Biol. 2006;581:37-41. doi: 10.1007/978-0-387-33012-9_5. Adv Exp Med Biol. 2006. PMID: 17037501 Free PMC article. No abstract available.

6

Proteolytic processing and deubiquitinating activity of papain-like proteases of human coronavirus NL63.

Chen Z, Wang Y, Ratia K, Mesecar AD, Wilkinson KD, Baker SC. Chen Z, et al. Among authors: mesecar ad. J Virol. 2007 Jun;81(11):6007-18. doi: 10.1128/JVI.02747-06. Epub 2007 Mar 28. J Virol. 2007. PMID: 17392370 Free PMC article.

7

Evaluating the 3C-like protease activity of SARS-Coronavirus: recommendations for standardized assays for drug discovery.

Grum-Tokars V, Ratia K, Begaye A, Baker SC, Mesecar AD. Grum-Tokars V, et al. Among authors: mesecar ad. Virus Res. 2008 Apr;133(1):63-73. doi: 10.1016/j.virusres.2007.02.015. Epub 2007 Mar 29. Virus Res. 2008. PMID: 17397958 Free PMC article.

8

Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors.

Ghosh AK, Xi K, Grum-Tokars V, Xu X, Ratia K, Fu W, Houser KV, Baker SC, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. Bioorg Med Chem Lett. 2007 Nov 1;17(21):5876-80. doi: 10.1016/j.bmcl.2007.08.031. Epub 2007 Aug 19. Bioorg Med Chem Lett. 2007. PMID: 17855091 Free PMC article.

9

Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors.

Ghosh AK, Gong G, Grum-Tokars V, Mulhearn DC, Baker SC, Coughlin M, Prabhakar BS, Sleeman K, Johnson ME, Mesecar AD. Ghosh AK, et al. Among authors: mesecar ad. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8. doi: 10.1016/j.bmcl.2008.08.082. Epub 2008 Aug 28. Bioorg Med Chem Lett. 2008. PMID: 18796354 Free PMC article.

10

A noncovalent class of papain-like protease/deubiquitinase inhibitors blocks SARS virus replication.

Ratia K, Pegan S, Takayama J, Sleeman K, Coughlin M, Baliji S, Chaudhuri R, Fu W, Prabhakar BS, Johnson ME, Baker SC, Ghosh AK, Mesecar AD. Ratia K, et al. Among authors: mesecar ad. Proc Natl Acad Sci U S A. 2008 Oct 21;105(42):16119-24. doi: 10.1073/pnas.0805240105. Epub 2008 Oct 13. Proc Natl Acad Sci U S A. 2008. PMID: 18852458 Free PMC article.

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