Demizu Y - Search Results

1

Deubiquitylase USP25 prevents degradation of BCR-ABL protein and ensures proliferation of Ph-positive leukemia cells.

Shibata N, Ohoka N, Tsuji G, Demizu Y, Miyawaza K, Ui-Tei K, Akiyama T, Naito M. Shibata N, et al. Among authors: demizu y. Oncogene. 2020 May;39(19):3867-3878. doi: 10.1038/s41388-020-1253-0. Epub 2020 Mar 12. Oncogene. 2020. PMID: 32203161

2

Design and synthesis of estrogen receptor degradation inducer based on a protein knockdown strategy.

Demizu Y, Okuhira K, Motoi H, Ohno A, Shoda T, Fukuhara K, Okuda H, Naito M, Kurihara M. Demizu Y, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1793-6. doi: 10.1016/j.bmcl.2011.11.086. Epub 2011 Nov 28. Bioorg Med Chem Lett. 2012. PMID: 22277276

3

Development of hybrid small molecules that induce degradation of estrogen receptor-alpha and necrotic cell death in breast cancer cells.

Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Nishimaki-Mogami T, Okuda H, Kurihara M, Naito M. Okuhira K, et al. Among authors: demizu y. Cancer Sci. 2013 Nov;104(11):1492-8. doi: 10.1111/cas.12272. Epub 2013 Oct 11. Cancer Sci. 2013. PMID: 23992566 Free PMC article.

4

Design and synthesis of tamoxifen derivatives as a selective estrogen receptor down-regulator.

Shoda T, Okuhira K, Kato M, Demizu Y, Inoue H, Naito M, Kurihara M. Shoda T, et al. Among authors: demizu y. Bioorg Med Chem Lett. 2014 Jan 1;24(1):87-9. doi: 10.1016/j.bmcl.2013.11.078. Epub 2013 Dec 4. Bioorg Med Chem Lett. 2014. PMID: 24332630

5

Development of cell-penetrating R7 fragment-conjugated helical peptides as inhibitors of estrogen receptor-mediated transcription.

Nagakubo T, Demizu Y, Kanda Y, Misawa T, Shoda T, Okuhira K, Sekino Y, Naito M, Kurihara M. Nagakubo T, et al. Among authors: demizu y. Bioconjug Chem. 2014 Nov 19;25(11):1921-4. doi: 10.1021/bc500480e. Epub 2014 Nov 7. Bioconjug Chem. 2014. PMID: 25375254

6

Synthesis and evaluation of tamoxifen derivatives with a long alkyl side chain as selective estrogen receptor down-regulators.

Shoda T, Kato M, Harada R, Fujisato T, Okuhira K, Demizu Y, Inoue H, Naito M, Kurihara M. Shoda T, et al. Among authors: demizu y. Bioorg Med Chem. 2015 Jul 1;23(13):3091-6. doi: 10.1016/j.bmc.2015.05.002. Epub 2015 May 11. Bioorg Med Chem. 2015. PMID: 26003343

7

Structural development of stabilized helical peptides as inhibitors of estrogen receptor (ER)-mediated transcription.

Demizu Y, Misawa T, Nagakubo T, Kanda Y, Okuhira K, Sekino Y, Naito M, Kurihara M. Demizu Y, et al. Bioorg Med Chem. 2015 Aug 1;23(15):4132-4138. doi: 10.1016/j.bmc.2015.06.067. Epub 2015 Jul 2. Bioorg Med Chem. 2015. PMID: 26183544

8

Effects of alkyl side chains and terminal hydrophilicity on vitamin D receptor (VDR) agonistic activity based on the diphenylpentane skeleton.

Misawa T, Yorioka M, Demizu Y, Noguchi-Yachide T, Ohoka N, Kurashima-Kinoshita M, Motoyoshi H, Nojiri H, Kittaka A, Makishima M, Naito M, Kurihara M. Misawa T, et al. Among authors: demizu y. Bioorg Med Chem Lett. 2015 Nov 15;25(22):5362-6. doi: 10.1016/j.bmcl.2015.09.030. Epub 2015 Sep 12. Bioorg Med Chem Lett. 2015. PMID: 26432035

9

A Helix-Stabilized Cell-Penetrating Peptide as an Intracellular Delivery Tool.

Yamashita H, Oba M, Misawa T, Tanaka M, Hattori T, Naito M, Kurihara M, Demizu Y. Yamashita H, et al. Among authors: demizu y. Chembiochem. 2016 Jan;17(2):137-40. doi: 10.1002/cbic.201500468. Epub 2015 Dec 3. Chembiochem. 2016. PMID: 26560998

10

Molecular Design, Synthesis, and Evaluation of SNIPER(ER) That Induces Proteasomal Degradation of ERα.

Okuhira K, Demizu Y, Hattori T, Ohoka N, Shibata N, Kurihara M, Naito M. Okuhira K, et al. Among authors: demizu y. Methods Mol Biol. 2016;1366:549-560. doi: 10.1007/978-1-4939-3127-9_42. Methods Mol Biol. 2016. PMID: 26585163

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