Ghattas MA - Search Results

1

The pharmacological chaperone N-n-butyl-deoxygalactonojirimycin enhances β-galactosidase processing and activity in fibroblasts of a patient with infantile GM1-gangliosidosis.

Mohamed FE, Al Sorkhy M, Ghattas MA, Al-Gazali L, Al-Dirbashi O, Al-Jasmi F, Ali BR. Mohamed FE, et al. Among authors: ghattas ma. Hum Genet. 2020 May;139(5):657-673. doi: 10.1007/s00439-020-02153-3. Epub 2020 Mar 26. Hum Genet. 2020. PMID: 32219518

2

Molecular dynamics simulations as a guide for modulating small molecule aggregation.

Nesabi A, Kalayan J, Al-Rawashdeh S, Ghattas MA, Bryce RA. Nesabi A, et al. Among authors: ghattas ma. J Comput Aided Mol Des. 2024 Mar 12;38(1):11. doi: 10.1007/s10822-024-00557-1. J Comput Aided Mol Des. 2024. PMID: 38470532 Free PMC article.

3

Druggability analysis and classification of protein tyrosine phosphatase active sites.

Ghattas MA, Raslan N, Sadeq A, Al Sorkhy M, Atatreh N. Ghattas MA, et al. Drug Des Devel Ther. 2016 Sep 30;10:3197-3209. doi: 10.2147/DDDT.S111443. eCollection 2016. Drug Des Devel Ther. 2016. PMID: 27757011 Free PMC article.

4

A de novo mutation in the X-linked PAK3 gene is the underlying cause of intellectual disability and macrocephaly in monozygotic twins.

Hertecant J, Komara M, Nagi A, Al-Zaabi O, Fathallah W, Cui H, Yang Y, Eng CM, Al Sorkhy M, Ghattas MA, Al-Gazali L, Ali BR. Hertecant J, et al. Among authors: ghattas ma. Eur J Med Genet. 2017 Apr;60(4):212-216. doi: 10.1016/j.ejmg.2017.01.004. Epub 2017 Jan 24. Eur J Med Genet. 2017. PMID: 28126652

5

Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidine compounds.

Atatreh N, Youssef AM, Ghattas MA, Al Sorkhy M, Alrawashdeh S, Al-Harbi KB, El-Ashmawy IM, Almundarij TI, Abdelghani AA, Abd-El-Aziz AS. Atatreh N, et al. Among authors: ghattas ma. Bioorg Chem. 2019 May;86:393-400. doi: 10.1016/j.bioorg.2019.02.014. Epub 2019 Feb 5. Bioorg Chem. 2019. PMID: 30763886

6

A Novel Homozygous Missense Variant in the NAGA Gene with Extreme Intrafamilial Phenotypic Heterogeneity.

Mohamed FE, Al Sorkhy M, Ghattas MA, Al-Zaabi N, Al-Shamsi A, Almansoori TM, Al-Gazali L, Al-Dirbashi OY, Al-Jasmi F, Ali BR. Mohamed FE, et al. Among authors: ghattas ma. J Mol Neurosci. 2020 Jan;70(1):45-55. doi: 10.1007/s12031-019-01398-6. Epub 2019 Aug 29. J Mol Neurosci. 2020. PMID: 31468281

7

Structure-based assessment and druggability classification of protein-protein interaction sites.

Alzyoud L, Bryce RA, Al Sorkhy M, Atatreh N, Ghattas MA. Alzyoud L, et al. Among authors: ghattas ma. Sci Rep. 2022 May 13;12(1):7975. doi: 10.1038/s41598-022-12105-8. Sci Rep. 2022. PMID: 35562538 Free PMC article.

8

The Discovery of Small Allosteric and Active Site Inhibitors of the SARS-CoV-2 Main Protease via Structure-Based Virtual Screening and Biological Evaluation.

Mahgoub RE, Mohamed FE, Alzyoud L, Ali BR, Ferreira J, Rabeh WM, AlNeyadi SS, Atatreh N, Ghattas MA. Mahgoub RE, et al. Among authors: ghattas ma. Molecules. 2022 Oct 9;27(19):6710. doi: 10.3390/molecules27196710. Molecules. 2022. PMID: 36235244 Free PMC article.

9

Computer-aided approaches reveal trihydroxychroman and pyrazolone derivatives as potential inhibitors of SARS-CoV-2 virus main protease.

Atatreh N, Hasan S, Ali BR, Ghattas MA. Atatreh N, et al. Among authors: ghattas ma. Acta Pharm. 2020 Dec 31;71(3):325-333. doi: 10.2478/acph-2021-0040. Print 2021 Sep 1. Acta Pharm. 2020. PMID: 36654095 Free article.

10

Novel compound heterozygous variants (c.971delA/c.542C > T) in SLC1A4 causes spastic tetraplegia, thin corpus callosum, and progressive microcephaly: a case report and mutational analysis.

Mohamed FE, Ghattas MA, Almansoori TM, Tabouni M, Baydoun I, Kizhakkedath P, John A, Alblooshi H, Shaukat Q, Al-Jasmi F. Mohamed FE, et al. Among authors: ghattas ma. Front Pediatr. 2023 Jul 12;11:1183574. doi: 10.3389/fped.2023.1183574. eCollection 2023. Front Pediatr. 2023. PMID: 37502193 Free PMC article.

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