Parker H - Search Results

1

Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma.

Taylor JT, Ellison S, Pandele A, Wood S, Nathan E, Forte G, Parker H, Zindy E, Elvin M, Dickson A, Williams KJ, Karabatsou K, McCabe M, McBain C, Bigger BW. Taylor JT, et al. Among authors: parker h. Neuro Oncol. 2020 Sep 29;22(9):1289-1301. doi: 10.1093/neuonc/noaa051. Neuro Oncol. 2020. PMID: 32227096 Free PMC article.

2

Non-myeloablative busulfan chimeric mouse models are less pro-inflammatory than head-shielded irradiation for studying immune cell interactions in brain tumours.

Youshani AS, Rowlston S, O'Leary C, Forte G, Parker H, Liao A, Telfer B, Williams K, Kamaly-Asl ID, Bigger BW. Youshani AS, et al. Among authors: parker h. J Neuroinflammation. 2019 Feb 5;16(1):25. doi: 10.1186/s12974-019-1410-y. J Neuroinflammation. 2019. PMID: 30722781 Free PMC article.

3

The role of innate immunity in mucopolysaccharide diseases.

Parker H, Bigger BW. Parker H, et al. J Neurochem. 2019 Mar;148(5):639-651. doi: 10.1111/jnc.14632. Epub 2018 Dec 13. J Neurochem. 2019. PMID: 30451296 Free PMC article. Review.

4

Pre-clinical Safety and Efficacy of Lentiviral Vector-Mediated Ex Vivo Stem Cell Gene Therapy for the Treatment of Mucopolysaccharidosis IIIA.

Ellison SM, Liao A, Wood S, Taylor J, Youshani AS, Rowlston S, Parker H, Armant M, Biffi A, Chan L, Farzaneh F, Wynn R, Jones SA, Heal P, Gaspar HB, Bigger BW. Ellison SM, et al. Among authors: parker h. Mol Ther Methods Clin Dev. 2019 Apr 6;13:399-413. doi: 10.1016/j.omtm.2019.04.001. eCollection 2019 Jun 14. Mol Ther Methods Clin Dev. 2019. PMID: 31044143 Free PMC article.

5

Haematopoietic stem cell gene therapy with IL-1Ra rescues cognitive loss in mucopolysaccharidosis IIIA.

Parker H, Ellison SM, Holley RJ, O'Leary C, Liao A, Asadi J, Glover E, Ghosh A, Jones S, Wilkinson FL, Brough D, Pinteaux E, Boutin H, Bigger BW. Parker H, et al. EMBO Mol Med. 2020 Mar 6;12(3):e11185. doi: 10.15252/emmm.201911185. Epub 2020 Feb 14. EMBO Mol Med. 2020. PMID: 32057196 Free PMC article.

6

Macrophage enzyme and reduced inflammation drive brain correction of mucopolysaccharidosis IIIB by stem cell gene therapy.

Holley RJ, Ellison SM, Fil D, O'Leary C, McDermott J, Senthivel N, Langford-Smith AWW, Wilkinson FL, D'Souza Z, Parker H, Liao A, Rowlston S, Gleitz HFE, Kan SH, Dickson PI, Bigger BW. Holley RJ, et al. Among authors: parker h. Brain. 2018 Jan 1;141(1):99-116. doi: 10.1093/brain/awx311. Brain. 2018. PMID: 29186350

7

An Improved Adeno-Associated Virus Vector for Neurological Correction of the Mouse Model of Mucopolysaccharidosis IIIA.

Gray AL, O'Leary C, Liao A, Agúndez L, Youshani AS, Gleitz HF, Parker H, Taylor JT, Danos O, Hocquemiller M, Palomar N, Linden RM, Henckaerts E, Holley RJ, Bigger BW. Gray AL, et al. Among authors: parker h. Hum Gene Ther. 2019 Sep;30(9):1052-1066. doi: 10.1089/hum.2018.189. Epub 2019 Jun 4. Hum Gene Ther. 2019. PMID: 31020862

8

Innate Immunity in Mucopolysaccharide Diseases.

Mandolfo O, Parker H, Bigger B. Mandolfo O, et al. Among authors: parker h. Int J Mol Sci. 2022 Feb 11;23(4):1999. doi: 10.3390/ijms23041999. Int J Mol Sci. 2022. PMID: 35216110 Free PMC article. Review.

9

High dose genistein in Sanfilippo syndrome: A randomised controlled trial.

Ghosh A, Rust S, Langford-Smith K, Weisberg D, Canal M, Breen C, Hepburn M, Tylee K, Vaz FM, Vail A, Wijburg F, O'Leary C, Parker H, Wraith JE, Bigger BW, Jones SA. Ghosh A, et al. Among authors: parker h. J Inherit Metab Dis. 2021 Sep;44(5):1248-1262. doi: 10.1002/jimd.12407. Epub 2021 Jun 13. J Inherit Metab Dis. 2021. PMID: 34047372 Clinical Trial.

10

A novel adeno-associated virus capsid with enhanced neurotropism corrects a lysosomal transmembrane enzyme deficiency.

Tordo J, O'Leary C, Antunes ASLM, Palomar N, Aldrin-Kirk P, Basche M, Bennett A, D'Souza Z, Gleitz H, Godwin A, Holley RJ, Parker H, Liao AY, Rouse P, Youshani AS, Dridi L, Martins C, Levade T, Stacey KB, Davis DM, Dyer A, Clément N, Björklund T, Ali RR, Agbandje-McKenna M, Rahim AA, Pshezhetsky A, Waddington SN, Linden RM, Bigger BW, Henckaerts E. Tordo J, et al. Among authors: parker h. Brain. 2018 Jul 1;141(7):2014-2031. doi: 10.1093/brain/awy126. Brain. 2018. PMID: 29788236 Free PMC article.

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