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Page 1
Proinflammatory immune cells disrupt angiogenesis and promote germinal matrix hemorrhage in prenatal human brain.
Chen J, Crouch EE, Zawadzki ME, Jacobs KA, Mayo LN, Choi JJ, Lin PY, Shaikh S, Tsui J, Gonzalez-Granero S, Waller S, Kelekar A, Kang G, Valenzuela EJ, Birrueta JO, Diafos LN, Wedderburn-Pugh K, Di Marco B, Xia W, Han CZ, Coufal NG, Glass CK, Fancy SPJ, Alfonso J, Kriegstein AR, Oldham MC, Garcia-Verdugo JM, Kutys ML, Lehtinen MK, Combes AJ, Huang EJ. Chen J, et al. Among authors: wedderburn pugh k. Nat Neurosci. 2024 Nov;27(11):2115-2129. doi: 10.1038/s41593-024-01769-2. Epub 2024 Sep 30. Nat Neurosci. 2024. PMID: 39349662 Free PMC article.
Profiling human brain vascular cells using single-cell transcriptomics and organoids.
Crouch EE, Diafos LN, Valenzuela EJ, Wedderburn-Pugh K, Birrueta JO, Caston J, Joseph T, Andrews MG, Bhaduri A, Huang EJ. Crouch EE, et al. Among authors: wedderburn pugh k. Nat Protoc. 2024 Mar;19(3):603-628. doi: 10.1038/s41596-023-00929-1. Epub 2023 Dec 15. Nat Protoc. 2024. PMID: 38102365 Free PMC article. Review.
Targeting ryanodine receptor type 2 to mitigate chemotherapy-induced neurocognitive impairments in mice.
Liu Y, Reiken S, Dridi H, Yuan Q, Mohammad KS, Trivedi T, Miotto MC, Wedderburn-Pugh K, Sittenfeld L, Kerley Y, Meyer JA, Peters JS, Persohn SC, Bedwell AA, Figueiredo LL, Suresh S, She Y, Soni RK, Territo PR, Marks AR, Guise TA. Liu Y, et al. Among authors: wedderburn pugh k. Sci Transl Med. 2023 Sep 27;15(715):eadf8977. doi: 10.1126/scitranslmed.adf8977. Epub 2023 Sep 27. Sci Transl Med. 2023. PMID: 37756377
Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.
Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-Granero S, Lozano JF, Vento M, Haeussler M, Paredes MF, Nakamura K, Garcia-Verdugo JM, Alvarez-Buylla A, Kriegstein AR, Huang EJ. Crouch EE, et al. Among authors: wedderburn pugh k. Cell. 2022 Sep 29;185(20):3753-3769.e18. doi: 10.1016/j.cell.2022.09.004. Cell. 2022. PMID: 36179668 Free PMC article.
Intracellular calcium leak as a therapeutic target for RYR1-related myopathies.
Kushnir A, Todd JJ, Witherspoon JW, Yuan Q, Reiken S, Lin H, Munce RH, Wajsberg B, Melville Z, Clarke OB, Wedderburn-Pugh K, Wronska A, Razaqyar MS, Chrismer IC, Shelton MO, Mankodi A, Grunseich C, Tarnopolsky MA, Tanji K, Hirano M, Riazi S, Kraeva N, Voermans NC, Gruber A, Allen C, Meilleur KG, Marks AR. Kushnir A, et al. Among authors: wedderburn pugh k. Acta Neuropathol. 2020 Jun;139(6):1089-1104. doi: 10.1007/s00401-020-02150-w. Epub 2020 Mar 31. Acta Neuropathol. 2020. PMID: 32236737 Free PMC article.