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Aminoacyl-tRNA synthetase inhibition activates a pathway that branches from the canonical amino acid response in mammalian cells.
Kim Y, Sundrud MS, Zhou C, Edenius M, Zocco D, Powers K, Zhang M, Mazitschek R, Rao A, Yeo CY, Noss EH, Brenner MB, Whitman M, Keller TL. Kim Y, et al. Among authors: yeo cy. Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):8900-8911. doi: 10.1073/pnas.1913788117. Epub 2020 Apr 6. Proc Natl Acad Sci U S A. 2020. PMID: 32253314 Free PMC article.
Halofuginone and other febrifugine derivatives inhibit prolyl-tRNA synthetase.
Keller TL, Zocco D, Sundrud MS, Hendrick M, Edenius M, Yum J, Kim YJ, Lee HK, Cortese JF, Wirth DF, Dignam JD, Rao A, Yeo CY, Mazitschek R, Whitman M. Keller TL, et al. Among authors: yeo cy. Nat Chem Biol. 2012 Feb 12;8(3):311-7. doi: 10.1038/nchembio.790. Nat Chem Biol. 2012. PMID: 22327401 Free PMC article.
A secreted tyrosine kinase acts in the extracellular environment.
Bordoli MR, Yum J, Breitkopf SB, Thon JN, Italiano JE Jr, Xiao J, Worby C, Wong SK, Lin G, Edenius M, Keller TL, Asara JM, Dixon JE, Yeo CY, Whitman M. Bordoli MR, et al. Among authors: yeo cy. Cell. 2014 Aug 28;158(5):1033-1044. doi: 10.1016/j.cell.2014.06.048. Cell. 2014. PMID: 25171405 Free PMC article.
A mutation in TGFB3 associated with a syndrome of low muscle mass, growth retardation, distal arthrogryposis and clinical features overlapping with Marfan and Loeys-Dietz syndrome.
Rienhoff HY Jr, Yeo CY, Morissette R, Khrebtukova I, Melnick J, Luo S, Leng N, Kim YJ, Schroth G, Westwick J, Vogel H, McDonnell N, Hall JG, Whitman M. Rienhoff HY Jr, et al. Among authors: yeo cy. Am J Med Genet A. 2013 Aug;161A(8):2040-6. doi: 10.1002/ajmg.a.36056. Epub 2013 Jul 3. Am J Med Genet A. 2013. PMID: 23824657 Free PMC article.
65 results