Zhang H - Search Results

1

Clopidogrel Resistance in a Murine Model of Diet-Induced Obesity Is Mediated by the Interleukin-1 Receptor and Overcome With DT-678.

Sun Y, Venugopal J, Guo C, Fan Y, Li J, Gong Y, Chen YE, Zhang H, Eitzman DT. Sun Y, et al. Among authors: zhang h. Arterioscler Thromb Vasc Biol. 2020 Jun;40(6):1533-1542. doi: 10.1161/ATVBAHA.120.314146. Epub 2020 Apr 9. Arterioscler Thromb Vasc Biol. 2020. PMID: 32268786 Free PMC article.

2

Formation, reactivity, and antiplatelet activity of mixed disulfide conjugates of clopidogrel.

Zhang H, Lauver DA, Lucchesi BR, Hollenberg PF. Zhang H, et al. Mol Pharmacol. 2013 Apr;83(4):848-56. doi: 10.1124/mol.112.084392. Epub 2013 Jan 24. Mol Pharmacol. 2013. PMID: 23348501 Free PMC article.

3

CYP-independent inhibition of platelet aggregation in rabbits by a mixed disulfide conjugate of clopidogrel.

Zhang H, Lauver DA, Hollenberg PF. Zhang H, et al. Thromb Haemost. 2014 Dec;112(6):1304-11. doi: 10.1160/TH14-04-0388. Epub 2014 Sep 18. Thromb Haemost. 2014. PMID: 25230737

4

Significant Improvement of Antithrombotic Responses to Clopidogrel by Use of a Novel Conjugate as Revealed in an Arterial Model of Thrombosis.

Zhang H, Lauver DA, Wang H, Sun D, Hollenberg PF, Chen YE, Osawa Y, Eitzman DT. Zhang H, et al. J Pharmacol Exp Ther. 2016 Oct;359(1):11-7. doi: 10.1124/jpet.116.236034. Epub 2016 Aug 10. J Pharmacol Exp Ther. 2016. PMID: 27511819 Free PMC article.

5

DT-678 inhibits platelet activation with lower tendency for bleeding compared to existing P2Y₁₂ antagonists.

Lauver DA, Kuszynski DS, Christian BD, Bernard MP, Teuber JP, Markham BE, Chen YE, Zhang H. Lauver DA, et al. Among authors: zhang h. Pharmacol Res Perspect. 2019 Jul 25;7(4):e00509. doi: 10.1002/prp2.509. eCollection 2019 Aug. Pharmacol Res Perspect. 2019. PMID: 31372229 Free PMC article.

6

Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign.

Huang X, Sun Y, Osawa Y, Chen YE, Zhang H. Huang X, et al. Among authors: zhang h. J Biol Chem. 2023 Aug;299(8):105050. doi: 10.1016/j.jbc.2023.105050. Epub 2023 Jul 13. J Biol Chem. 2023. PMID: 37451479 Free PMC article.

7

The Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering.

Sun Y, Huang X, Osawa Y, Chen YE, Zhang H. Sun Y, et al. Among authors: zhang h. Molecules. 2023 Jul 12;28(14):5353. doi: 10.3390/molecules28145353. Molecules. 2023. PMID: 37513226 Free PMC article. Review.

8

Mechanism-based inactivation of human cytochrome P450 2B6 by clopidogrel: involvement of both covalent modification of cysteinyl residue 475 and loss of heme.

Zhang H, Amunugama H, Ney S, Cooper N, Hollenberg PF. Zhang H, et al. Mol Pharmacol. 2011 Nov;80(5):839-47. doi: 10.1124/mol.111.073783. Epub 2011 Aug 23. Mol Pharmacol. 2011. PMID: 21862689 Free PMC article.

9

Formation of the thiol conjugates and active metabolite of clopidogrel by human liver microsomes.

Zhang H, Lau WC, Hollenberg PF. Zhang H, et al. Mol Pharmacol. 2012 Aug;82(2):302-9. doi: 10.1124/mol.112.079061. Epub 2012 May 14. Mol Pharmacol. 2012. PMID: 22584220 Free PMC article.

10

High-throughput fluorescence assay for cytochrome P450 mechanism-based inactivators.

Kenaan C, Zhang H, Hollenberg PF. Kenaan C, et al. Among authors: zhang h. Methods Mol Biol. 2013;987:61-9. doi: 10.1007/978-1-62703-321-3_5. Methods Mol Biol. 2013. PMID: 23475667

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