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Unbiased proteomics identifies plasminogen activator inhibitor-1 as a negative regulator of endothelial nitric oxide synthase.
Garcia V, Park EJ, Siragusa M, Frohlich F, Mahfuzul Haque M, Pascale JV, Heberlein KR, Isakson BE, Stuehr DJ, Sessa WC. Garcia V, et al. Among authors: siragusa m. Proc Natl Acad Sci U S A. 2020 Apr 28;117(17):9497-9507. doi: 10.1073/pnas.1918761117. Epub 2020 Apr 16. Proc Natl Acad Sci U S A. 2020. PMID: 32300005 Free PMC article.
Endothelial miR-17∼92 cluster negatively regulates arteriogenesis via miRNA-19 repression of WNT signaling.
Landskroner-Eiger S, Qiu C, Perrotta P, Siragusa M, Lee MY, Ulrich V, Luciano AK, Zhuang ZW, Corti F, Simons M, Montgomery RL, Wu D, Yu J, Sessa WC. Landskroner-Eiger S, et al. Among authors: siragusa m. Proc Natl Acad Sci U S A. 2015 Oct 13;112(41):12812-7. doi: 10.1073/pnas.1507094112. Epub 2015 Sep 28. Proc Natl Acad Sci U S A. 2015. PMID: 26417068 Free PMC article.
Nitric oxide maintains endothelial redox homeostasis through PKM2 inhibition.
Siragusa M, Thöle J, Bibli SI, Luck B, Loot AE, de Silva K, Wittig I, Heidler J, Stingl H, Randriamboavonjy V, Kohlstedt K, Brüne B, Weigert A, Fisslthaler B, Fleming I. Siragusa M, et al. EMBO J. 2019 Sep 2;38(17):e100938. doi: 10.15252/embj.2018100938. Epub 2019 Jul 22. EMBO J. 2019. PMID: 31328803 Free PMC article.
Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure.
Iring A, Jin YJ, Albarrán-Juárez J, Siragusa M, Wang S, Dancs PT, Nakayama A, Tonack S, Chen M, Künne C, Sokol AM, Günther S, Martínez A, Fleming I, Wettschureck N, Graumann J, Weinstein LS, Offermanns S. Iring A, et al. Among authors: siragusa m. J Clin Invest. 2019 Jun 17;129(7):2775-2791. doi: 10.1172/JCI123825. eCollection 2019 Jun 17. J Clin Invest. 2019. PMID: 31205027 Free PMC article.
Loss of Endothelial Cytochrome P450 Reductase Induces Vascular Dysfunction in Mice.
Malacarne PF, Ratiu C, Gajos-Draus A, Müller N, Lopez M, Pflüger-Müller B, Ding X, Warwick T, Oo J, Siragusa M, Angioni C, Günther S, Weigert A, Geißlinger G, Lütjohann D, Schunck WH, Fleming I, Brandes RP, Rezende F. Malacarne PF, et al. Among authors: siragusa m. Hypertension. 2022 Jun;79(6):1216-1226. doi: 10.1161/HYPERTENSIONAHA.121.18752. Epub 2022 Mar 31. Hypertension. 2022. PMID: 35354305
137 results