Adams JM - Search Results

1

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target.

Iyer S, Uren RT, Dengler MA, Shi MX, Uno E, Adams JM, Dewson G, Kluck RM. Iyer S, et al. Among authors: adams jm. Cell Death Dis. 2020 Apr 23;11(4):268. doi: 10.1038/s41419-020-2463-7. Cell Death Dis. 2020. PMID: 32327636 Free PMC article.

2

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.

Willis SN, Fletcher JI, Kaufmann T, van Delft MF, Chen L, Czabotar PE, Ierino H, Lee EF, Fairlie WD, Bouillet P, Strasser A, Kluck RM, Adams JM, Huang DC. Willis SN, et al. Among authors: adams jm. Science. 2007 Feb 9;315(5813):856-9. doi: 10.1126/science.1133289. Science. 2007. PMID: 17289999

3

Mitochondrial permeabilization relies on BH3 ligands engaging multiple prosurvival Bcl-2 relatives, not Bak.

Uren RT, Dewson G, Chen L, Coyne SC, Huang DC, Adams JM, Kluck RM. Uren RT, et al. Among authors: adams jm. J Cell Biol. 2007 Apr 23;177(2):277-87. doi: 10.1083/jcb.200606065. J Cell Biol. 2007. PMID: 17452531 Free PMC article.

4

To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions.

Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, Colman PM, Kluck RM. Dewson G, et al. Among authors: adams jm. Mol Cell. 2008 May 9;30(3):369-80. doi: 10.1016/j.molcel.2008.04.005. Mol Cell. 2008. PMID: 18471982 Free article.

5

Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.

Dewson G, Kratina T, Czabotar P, Day CL, Adams JM, Kluck RM. Dewson G, et al. Among authors: adams jm. Mol Cell. 2009 Nov 25;36(4):696-703. doi: 10.1016/j.molcel.2009.11.008. Mol Cell. 2009. PMID: 19941828 Free article.

6

Bax crystal structures reveal how BH3 domains activate Bax and nucleate its oligomerization to induce apoptosis.

Czabotar PE, Westphal D, Dewson G, Ma S, Hockings C, Fairlie WD, Lee EF, Yao S, Robin AY, Smith BJ, Huang DC, Kluck RM, Adams JM, Colman PM. Czabotar PE, et al. Among authors: adams jm. Cell. 2013 Jan 31;152(3):519-31. doi: 10.1016/j.cell.2012.12.031. Cell. 2013. PMID: 23374347 Free article.

7

Apoptotic pore formation is associated with in-plane insertion of Bak or Bax central helices into the mitochondrial outer membrane.

Westphal D, Dewson G, Menard M, Frederick P, Iyer S, Bartolo R, Gibson L, Czabotar PE, Smith BJ, Adams JM, Kluck RM. Westphal D, et al. Among authors: adams jm. Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4076-85. doi: 10.1073/pnas.1415142111. Epub 2014 Sep 16. Proc Natl Acad Sci U S A. 2014. PMID: 25228770 Free PMC article.

8

BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.

Dengler MA, Robin AY, Gibson L, Li MX, Sandow JJ, Iyer S, Webb AI, Westphal D, Dewson G, Adams JM. Dengler MA, et al. Among authors: adams jm. Cell Rep. 2019 Apr 9;27(2):359-373.e6. doi: 10.1016/j.celrep.2019.03.040. Cell Rep. 2019. PMID: 30970242 Free article.

9

BAX mitochondrial integration is regulated allosterically by its α1-α2 loop.

Dengler MA, Gibson L, Adams JM. Dengler MA, et al. Among authors: adams jm. Cell Death Differ. 2021 Dec;28(12):3270-3281. doi: 10.1038/s41418-021-00815-x. Epub 2021 Jun 16. Cell Death Differ. 2021. PMID: 34135480 Free PMC article.

10

Proapoptotic Bak is sequestered by Mcl-1 and Bcl-xL, but not Bcl-2, until displaced by BH3-only proteins.

Willis SN, Chen L, Dewson G, Wei A, Naik E, Fletcher JI, Adams JM, Huang DC. Willis SN, et al. Among authors: adams jm. Genes Dev. 2005 Jun 1;19(11):1294-305. doi: 10.1101/gad.1304105. Epub 2005 May 18. Genes Dev. 2005. PMID: 15901672 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

674 results

Search Page

Filters