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Page 1
Synthesis and biological evaluation of novel imidazol-1-ylacetic acid derivatives as non-brain penetrant bombesin receptor subtype-3 (BRS-3) agonists.
Kiyotsuka Y, Shimada K, Kobayashi S, Suzuki M, Akiu M, Asano M, Sogawa Y, Hara T, Konishi M, Abe-Ohya R, Izumi M, Nagai Y, Yoshida K, Abe Y, Takamori H, Takahashi H. Kiyotsuka Y, et al. Bioorg Med Chem Lett. 2016 Sep 1;26(17):4205-10. doi: 10.1016/j.bmcl.2016.07.056. Epub 2016 Jul 25. Bioorg Med Chem Lett. 2016. PMID: 27491709
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide.
Uto Y, Ogata T, Harada J, Kiyotsuka Y, Ueno Y, Miyazawa Y, Kurata H, Deguchi T, Watanabe N, Takagi T, Wakimoto S, Okuyama R, Abe M, Kurikawa N, Kawamura S, Yamato M, Osumi J. Uto Y, et al. Among authors: kiyotsuka y. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4151-8. doi: 10.1016/j.bmcl.2009.05.119. Epub 2009 Jun 2. Bioorg Med Chem Lett. 2009. PMID: 19540759
Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part II: Identification of 4-ethylamino-3-(2-hydroxyethoxy)-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide and its biological evaluation.
Uto Y, Ogata T, Kiyotsuka Y, Miyazawa Y, Ueno Y, Kurata H, Deguchi T, Yamada M, Watanabe N, Takagi T, Wakimoto S, Okuyama R, Konishi M, Kurikawa N, Kono K, Osumi J. Uto Y, et al. Among authors: kiyotsuka y. Bioorg Med Chem Lett. 2009 Aug 1;19(15):4159-66. doi: 10.1016/j.bmcl.2009.05.123. Epub 2009 Jun 6. Bioorg Med Chem Lett. 2009. PMID: 19541482
Novel benzoylpiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 6-[4-(2-methylbenzoyl)piperidin-1-yl]pyridazine-3-carboxylic acid (2-hydroxy-2-pyridin-3-ylethyl)amide and its plasma triglyceride-lowering effects in Zucker fatty rats.
Uto Y, Ogata T, Kiyotsuka Y, Ueno Y, Miyazawa Y, Kurata H, Deguchi T, Watanabe N, Konishi M, Okuyama R, Kurikawa N, Takagi T, Wakimoto S, Ohsumi J. Uto Y, et al. Among authors: kiyotsuka y. Bioorg Med Chem Lett. 2010 Jan 1;20(1):341-5. doi: 10.1016/j.bmcl.2009.10.101. Epub 2009 Oct 29. Bioorg Med Chem Lett. 2010. PMID: 19926281
Novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors: Identification of 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-5-(trifluoromethyl)-3,4-dihydrospiro[chromene-2,4'-piperidine].
Uto Y, Kiyotsuka Y, Ueno Y, Miyazawa Y, Kurata H, Ogata T, Deguchi T, Yamada M, Watanabe N, Konishi M, Kurikawa N, Takagi T, Wakimoto S, Kono K, Ohsumi J. Uto Y, et al. Among authors: kiyotsuka y. Bioorg Med Chem Lett. 2010 Jan 15;20(2):746-54. doi: 10.1016/j.bmcl.2009.11.043. Epub 2009 Nov 14. Bioorg Med Chem Lett. 2010. PMID: 20006498
Synthesis and evaluation of novel stearoyl-CoA desaturase 1 inhibitors: 1'-{6-[5-(pyridin-3-ylmethyl)-1,3,4-oxadiazol-2-yl]pyridazin-3-yl}-3,4-dihydrospiro[chromene-2,4'-piperidine] analogs.
Uto Y, Ueno Y, Kiyotsuka Y, Miyazawa Y, Kurata H, Ogata T, Yamada M, Deguchi T, Konishi M, Takagi T, Wakimoto S, Ohsumi J. Uto Y, et al. Among authors: kiyotsuka y. Eur J Med Chem. 2010 Nov;45(11):4788-96. doi: 10.1016/j.ejmech.2010.07.044. Epub 2010 Aug 4. Eur J Med Chem. 2010. PMID: 20801551
17 results