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In vivo selective inhibition of TRPC6 by antagonist BI 749327 ameliorates fibrosis and dysfunction in cardiac and renal disease.
Lin BL, Matera D, Doerner JF, Zheng N, Del Camino D, Mishra S, Bian H, Zeveleva S, Zhen X, Blair NT, Chong JA, Hessler DP, Bedja D, Zhu G, Muller GK, Ranek MJ, Pantages L, McFarland M, Netherton MR, Berry A, Wong D, Rast G, Qian HS, Weldon SM, Kuo JJ, Sauer A, Sarko C, Moran MM, Kass DA, Pullen SS. Lin BL, et al. Among authors: mishra s. Proc Natl Acad Sci U S A. 2019 May 14;116(20):10156-10161. doi: 10.1073/pnas.1815354116. Epub 2019 Apr 26. Proc Natl Acad Sci U S A. 2019. PMID: 31028142 Free PMC article.
Targeting Protein Kinase G to Treat Cardiac Proteotoxicity.
Oeing CU, Mishra S, Dunkerly-Eyring BL, Ranek MJ. Oeing CU, et al. Among authors: mishra s. Front Physiol. 2020 Jul 28;11:858. doi: 10.3389/fphys.2020.00858. eCollection 2020. Front Physiol. 2020. PMID: 32848832 Free PMC article. Review.
CHIP phosphorylation by protein kinase G enhances protein quality control and attenuates cardiac ischemic injury.
Ranek MJ, Oeing C, Sanchez-Hodge R, Kokkonen-Simon KM, Dillard D, Aslam MI, Rainer PP, Mishra S, Dunkerly-Eyring B, Holewinski RJ, Virus C, Zhang H, Mannion MM, Agrawal V, Hahn V, Lee DI, Sasaki M, Van Eyk JE, Willis MS, Page RC, Schisler JC, Kass DA. Ranek MJ, et al. Among authors: mishra s. Nat Commun. 2020 Oct 20;11(1):5237. doi: 10.1038/s41467-020-18980-x. Nat Commun. 2020. PMID: 33082318 Free PMC article.
MTORC1-Regulated Metabolism Controlled by TSC2 Limits Cardiac Reperfusion Injury.
Oeing CU, Jun S, Mishra S, Dunkerly-Eyring BL, Chen A, Grajeda MI, Tahir UA, Gerszten RE, Paolocci N, Ranek MJ, Kass DA. Oeing CU, et al. Among authors: mishra s. Circ Res. 2021 Mar 5;128(5):639-651. doi: 10.1161/CIRCRESAHA.120.317710. Epub 2021 Jan 6. Circ Res. 2021. PMID: 33401933 Free PMC article.
7,498 results