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MKRN3 inhibits the reproductive axis through actions in kisspeptin-expressing neurons.
Abreu AP, Toro CA, Song YB, Navarro VM, Bosch MA, Eren A, Liang JN, Carroll RS, Latronico AC, Rønnekleiv OK, Aylwin CF, Lomniczi A, Ojeda S, Kaiser UB. Abreu AP, et al. Among authors: carroll rs. J Clin Invest. 2020 Aug 3;130(8):4486-4500. doi: 10.1172/JCI136564. J Clin Invest. 2020. PMID: 32407292 Free PMC article.
Increased neurokinin B (Tac2) expression in the mouse arcuate nucleus is an early marker of pubertal onset with differential sensitivity to sex steroid-negative feedback than Kiss1.
Gill JC, Navarro VM, Kwong C, Noel SD, Martin C, Xu S, Clifton DK, Carroll RS, Steiner RA, Kaiser UB. Gill JC, et al. Among authors: carroll rs. Endocrinology. 2012 Oct;153(10):4883-93. doi: 10.1210/en.2012-1529. Epub 2012 Aug 14. Endocrinology. 2012. PMID: 22893725 Free PMC article.
Central precocious puberty caused by mutations in the imprinted gene MKRN3.
Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Abreu AP, et al. Among authors: carroll rs. N Engl J Med. 2013 Jun 27;368(26):2467-75. doi: 10.1056/NEJMoa1302160. Epub 2013 Jun 5. N Engl J Med. 2013. PMID: 23738509 Free PMC article.
156 results