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Arginine Depletion Therapy with ADI-PEG20 Limits Tumor Growth in Argininosuccinate Synthase-Deficient Ovarian Cancer, Including Small-Cell Carcinoma of the Ovary, Hypercalcemic Type.
Ji JX, Cochrane DR, Tessier-Cloutier B, Chen SY, Ho G, Pathak KV, Alcazar IN, Farnell D, Leung S, Cheng A, Chow C, Colborne S, Negri GL, Kommoss F, Karnezis A, Morin GB, McAlpine JN, Gilks CB, Weissman BE, Trent JM, Hoang L, Pirrotte P, Wang Y, Huntsman DG. Ji JX, et al. Among authors: wang y. Clin Cancer Res. 2020 Aug 15;26(16):4402-4413. doi: 10.1158/1078-0432.CCR-19-1905. Epub 2020 May 14. Clin Cancer Res. 2020. PMID: 32409304 Free PMC article.
A functional proteogenomic analysis of endometrioid and clear cell carcinomas using reverse phase protein array and mutation analysis: protein expression is histotype-specific and loss of ARID1A/BAF250a is associated with AKT phosphorylation.
Wiegand KC, Hennessy BT, Leung S, Wang Y, Ju Z, McGahren M, Kalloger SE, Finlayson S, Stemke-Hale K, Lu Y, Zhang F, Anglesio MS, Gilks B, Mills GB, Huntsman DG, Carey MS. Wiegand KC, et al. Among authors: wang y. BMC Cancer. 2014 Feb 22;14:120. doi: 10.1186/1471-2407-14-120. BMC Cancer. 2014. PMID: 24559118 Free PMC article.
p53 is positively regulated by miR-542-3p.
Wang Y, Huang JW, Castella M, Huntsman DG, Taniguchi T. Wang Y, et al. Cancer Res. 2014 Jun 15;74(12):3218-27. doi: 10.1158/0008-5472.CAN-13-1706. Epub 2014 Apr 24. Cancer Res. 2014. PMID: 24762395 Free PMC article.
Dual loss of the SWI/SNF complex ATPases SMARCA4/BRG1 and SMARCA2/BRM is highly sensitive and specific for small cell carcinoma of the ovary, hypercalcaemic type.
Karnezis AN, Wang Y, Ramos P, Hendricks WP, Oliva E, D'Angelo E, Prat J, Nucci MR, Nielsen TO, Chow C, Leung S, Kommoss F, Kommoss S, Silva A, Ronnett BM, Rabban JT, Bowtell DD, Weissman BE, Trent JM, Gilks CB, Huntsman DG. Karnezis AN, et al. Among authors: wang y. J Pathol. 2016 Feb;238(3):389-400. doi: 10.1002/path.4633. Epub 2015 Dec 21. J Pathol. 2016. PMID: 26356327 Free PMC article.
Loss of the tumor suppressor SMARCA4 in small cell carcinoma of the ovary, hypercalcemic type (SCCOHT).
Ramos P, Karnezis AN, Hendricks WP, Wang Y, Tembe W, Zismann VL, Legendre C, Liang WS, Russell ML, Craig DW, Farley JH, Monk BJ, Anthony SP, Sekulic A, Cunliffe HE, Huntsman DG, Trent JM. Ramos P, et al. Among authors: wang y. Rare Dis. 2014 Nov 3;2(1):e967148. doi: 10.4161/2167549X.2014.967148. eCollection 2014. Rare Dis. 2014. PMID: 26942101 Free PMC article.
ARID1A-mutated ovarian cancers depend on HDAC6 activity.
Bitler BG, Wu S, Park PH, Hai Y, Aird KM, Wang Y, Zhai Y, Kossenkov AV, Vara-Ailor A, Rauscher FJ III, Zou W, Speicher DW, Huntsman DG, Conejo-Garcia JR, Cho KR, Christianson DW, Zhang R. Bitler BG, et al. Among authors: wang y. Nat Cell Biol. 2017 Aug;19(8):962-973. doi: 10.1038/ncb3582. Epub 2017 Jul 24. Nat Cell Biol. 2017. PMID: 28737768 Free PMC article.
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