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The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
Carrat GR, Haythorne E, Tomas A, Haataja L, Müller A, Arvan P, Piunti A, Cheng K, Huang M, Pullen TJ, Georgiadou E, Stylianides T, Amirruddin NS, Salem V, Distaso W, Cakebread A, Heesom KJ, Lewis PA, Hodson DJ, Briant LJ, Fung ACH, Sessions RB, Alpy F, Kong APS, Benke PI, Torta F, Teo AKK, Leclerc I, Solimena M, Wigley DB, Rutter GA. Carrat GR, et al. Among authors: alpy f. Mol Metab. 2020 Oct;40:101015. doi: 10.1016/j.molmet.2020.101015. Epub 2020 May 13. Mol Metab. 2020. PMID: 32416313 Free PMC article.
Perispeckles are major assembly sites for the exon junction core complex.
Daguenet E, Baguet A, Degot S, Schmidt U, Alpy F, Wendling C, Spiegelhalter C, Kessler P, Rio MC, Le Hir H, Bertrand E, Tomasetto C. Daguenet E, et al. Among authors: alpy f. Mol Biol Cell. 2012 May;23(9):1765-82. doi: 10.1091/mbc.E12-01-0040. Epub 2012 Mar 14. Mol Biol Cell. 2012. PMID: 22419818 Free PMC article.
MENTHO, a MLN64 homologue devoid of the START domain.
Alpy F, Wendling C, Rio MC, Tomasetto C. Alpy F, et al. J Biol Chem. 2002 Dec 27;277(52):50780-7. doi: 10.1074/jbc.M208290200. Epub 2002 Oct 18. J Biol Chem. 2002. PMID: 12393907 Free article.
START ships lipids across interorganelle space.
Alpy F, Tomasetto C. Alpy F, et al. Biochimie. 2014 Jan;96:85-95. doi: 10.1016/j.biochi.2013.09.015. Epub 2013 Sep 25. Biochimie. 2014. PMID: 24076129 Review.
FFAT motif phosphorylation controls formation and lipid transfer function of inter-organelle contacts.
Di Mattia T, Martinet A, Ikhlef S, McEwen AG, Nominé Y, Wendling C, Poussin-Courmontagne P, Voilquin L, Eberling P, Ruffenach F, Cavarelli J, Slee J, Levine TP, Drin G, Tomasetto C, Alpy F. Di Mattia T, et al. Among authors: alpy f. EMBO J. 2020 Dec 1;39(23):e104369. doi: 10.15252/embj.2019104369. Epub 2020 Oct 30. EMBO J. 2020. PMID: 33124732 Free PMC article.
48 results