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The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
Carrat GR, Haythorne E, Tomas A, Haataja L, Müller A, Arvan P, Piunti A, Cheng K, Huang M, Pullen TJ, Georgiadou E, Stylianides T, Amirruddin NS, Salem V, Distaso W, Cakebread A, Heesom KJ, Lewis PA, Hodson DJ, Briant LJ, Fung ACH, Sessions RB, Alpy F, Kong APS, Benke PI, Torta F, Teo AKK, Leclerc I, Solimena M, Wigley DB, Rutter GA. Carrat GR, et al. Among authors: heesom kj. Mol Metab. 2020 Oct;40:101015. doi: 10.1016/j.molmet.2020.101015. Epub 2020 May 13. Mol Metab. 2020. PMID: 32416313 Free PMC article.
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication.
Yaron TM, Heaton BE, Levy TM, Johnson JL, Jordan TX, Cohen BM, Kerelsky A, Lin TY, Liberatore KM, Bulaon DK, Van Nest SJ, Koundouros N, Kastenhuber ER, Mercadante MN, Shobana-Ganesh K, He L, Schwartz RE, Chen S, Weinstein H, Elemento O, Piskounova E, Nilsson-Payant BE, Lee G, Trimarco JD, Burke KN, Hamele CE, Chaparian RR, Harding AT, Tata A, Zhu X, Tata PR, Smith CM, Possemato AP, Tkachev SL, Hornbeck PV, Beausoleil SA, Anand SK, Aguet F, Getz G, Davidson AD, Heesom K, Kavanagh-Williamson M, Matthews DA, tenOever BR, Cantley LC, Blenis J, Heaton NS. Yaron TM, et al. Sci Signal. 2022 Oct 25;15(757):eabm0808. doi: 10.1126/scisignal.abm0808. Epub 2022 Oct 25. Sci Signal. 2022. PMID: 36282911 Free PMC article.
A role for NPY-NPY2R signaling in albuminuric kidney disease.
Lay AC, Barrington AF, Hurcombe JA, Ramnath RD, Graham M, Lewis PA, Wilson MC, Heesom KJ, Butler MJ, Perrett RM, Neal CR, Herbert E, Mountjoy E, Atan D, Nair V, Ju W, Nelson RG, Kretzler M, Satchell SC, McArdle CA, Welsh GI, Coward RJM. Lay AC, et al. Among authors: heesom kj. Proc Natl Acad Sci U S A. 2020 Jul 7;117(27):15862-15873. doi: 10.1073/pnas.2004651117. Epub 2020 Jun 19. Proc Natl Acad Sci U S A. 2020. PMID: 32561647 Free PMC article.
Characterisation of the transcriptome and proteome of SARS-CoV-2 reveals a cell passage induced in-frame deletion of the furin-like cleavage site from the spike glycoprotein.
Davidson AD, Williamson MK, Lewis S, Shoemark D, Carroll MW, Heesom KJ, Zambon M, Ellis J, Lewis PA, Hiscox JA, Matthews DA. Davidson AD, et al. Among authors: heesom kj. Genome Med. 2020 Jul 28;12(1):68. doi: 10.1186/s13073-020-00763-0. Genome Med. 2020. PMID: 32723359 Free PMC article.
Effect of cardioplegic arrest and reperfusion on left and right ventricular proteome/phosphoproteome in patients undergoing surgery for coronary or aortic valve disease.
Abdul-Ghani S, Skeffington KL, Kim M, Moscarelli M, Lewis PA, Heesom K, Fiorentino F, Emanueli C, Reeves BC, Punjabi PP, Angelini GD, Suleiman MS. Abdul-Ghani S, et al. Int J Mol Med. 2022 Jun;49(6):77. doi: 10.3892/ijmm.2022.5133. Epub 2022 Apr 15. Int J Mol Med. 2022. PMID: 35425992 Free PMC article.
Insulin action on metabolism.
Heesom KJ, Harbeck M, Kahn CR, Denton RM. Heesom KJ, et al. Diabetologia. 1997 Oct;40 Suppl 3:B3-9. doi: 10.1007/BF03168179. Diabetologia. 1997. PMID: 9345638 No abstract available.
RhoG protein regulates platelet granule secretion and thrombus formation in mice.
Goggs R, Harper MT, Pope RJ, Savage JS, Williams CM, Mundell SJ, Heesom KJ, Bass M, Mellor H, Poole AW. Goggs R, et al. Among authors: heesom kj. J Biol Chem. 2013 Nov 22;288(47):34217-34229. doi: 10.1074/jbc.M113.504100. Epub 2013 Oct 8. J Biol Chem. 2013. PMID: 24106270 Free PMC article.
159 results