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A fully human anti-BMP6 antibody reduces the need for erythropoietin in rodent models of the anemia of chronic disease.
Petzer V, Tymoszuk P, Asshoff M, Carvalho J, Papworth J, Deantonio C, Bayliss L, Wake MS, Seifert M, Brigo N, Valente de Souza L, Hilbe R, Grubwieser P, Demetz E, Dichtl S, Volani C, Berger S, Böhm F, Hoffmann A, Pfeifhofer-Obermair C, von Raffay L, Sopper S, Arndt S, Bosserhoff A, Kautz L, Perrier P, Nairz M, Wolf D, Weiss G, Germaschewski V, Theurl I. Petzer V, et al. Among authors: tymoszuk p. Blood. 2020 Aug 27;136(9):1080-1090. doi: 10.1182/blood.2019004653. Blood. 2020. PMID: 32438400 Free PMC article.
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver.
Theurl I, Hilgendorf I, Nairz M, Tymoszuk P, Haschka D, Asshoff M, He S, Gerhardt LM, Holderried TA, Seifert M, Sopper S, Fenn AM, Anzai A, Rattik S, McAlpine C, Theurl M, Wieghofer P, Iwamoto Y, Weber GF, Harder NK, Chousterman BG, Arvedson TL, McKee M, Wang F, Lutz OM, Rezoagli E, Babitt JL, Berra L, Prinz M, Nahrendorf M, Weiss G, Weissleder R, Lin HY, Swirski FK. Theurl I, et al. Among authors: tymoszuk p. Nat Med. 2016 Aug;22(8):945-51. doi: 10.1038/nm.4146. Epub 2016 Jul 18. Nat Med. 2016. PMID: 27428900 Free PMC article.
Momelotinib inhibits ACVR1/ALK2, decreases hepcidin production, and ameliorates anemia of chronic disease in rodents.
Asshoff M, Petzer V, Warr MR, Haschka D, Tymoszuk P, Demetz E, Seifert M, Posch W, Nairz M, Maciejewski P, Fowles P, Burns CJ, Smith G, Wagner KU, Weiss G, Whitney JA, Theurl I. Asshoff M, et al. Among authors: tymoszuk p. Blood. 2017 Mar 30;129(13):1823-1830. doi: 10.1182/blood-2016-09-740092. Epub 2017 Feb 10. Blood. 2017. PMID: 28188131 Free PMC article.
Correction for Wu et al., "Salmonella Utilizes Zinc To Subvert Antimicrobial Host Defense of Macrophages via Modulation of NF-κB Signaling".
Wu A, Tymoszuk P, Haschka D, Heeke S, Dichtl S, Petzer V, Seifert M, Hilbe R, Sopper S, Talasz H, Bumann D, Lass-Flörl C, Theurl I, Zhang K, Weiss G. Wu A, et al. Among authors: tymoszuk p. Infect Immun. 2018 Feb 20;86(3):e00881-17. doi: 10.1128/IAI.00881-17. Print 2018 Mar. Infect Immun. 2018. PMID: 29463686 Free PMC article. No abstract available.
The crucial impact of iron deficiency definition for the course of precapillary pulmonary hypertension.
Sonnweber T, Nairz M, Theurl I, Petzer V, Tymoszuk P, Haschka D, Rieger E, Kaessmann B, Deri M, Watzinger K, Steringer-Mascherbauer R, Tancevski I, Weiss G, Löffler-Ragg J. Sonnweber T, et al. Among authors: tymoszuk p. PLoS One. 2018 Aug 30;13(8):e0203396. doi: 10.1371/journal.pone.0203396. eCollection 2018. PLoS One. 2018. PMID: 30161261 Free PMC article.
69 results