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T cells with dysfunctional mitochondria induce multimorbidity and premature senescence.
Desdín-Micó G, Soto-Heredero G, Aranda JF, Oller J, Carrasco E, Gabandé-Rodríguez E, Blanco EM, Alfranca A, Cussó L, Desco M, Ibañez B, Gortazar AR, Fernández-Marcos P, Navarro MN, Hernaez B, Alcamí A, Baixauli F, Mittelbrunn M. Desdín-Micó G, et al. Science. 2020 Jun 19;368(6497):1371-1376. doi: 10.1126/science.aax0860. Epub 2020 May 21. Science. 2020. PMID: 32439659
The sirtuin family in cancer.
Costa-Machado LF, Fernandez-Marcos PJ. Costa-Machado LF, et al. Cell Cycle. 2019 Sep;18(18):2164-2196. doi: 10.1080/15384101.2019.1634953. Epub 2019 Jul 25. Cell Cycle. 2019. PMID: 31251117 Free PMC article.
Activation of p21 limits acute lung injury and induces early senescence after acid aspiration and mechanical ventilation.
Blázquez-Prieto J, Huidobro C, López-Alonso I, Amado-Rodriguez L, Martín-Vicente P, López-Martínez C, Crespo I, Pantoja C, Fernandez-Marcos PJ, Serrano M, Sznajder JI, Albaiceta GM. Blázquez-Prieto J, et al. Transl Res. 2021 Jul;233:104-116. doi: 10.1016/j.trsl.2021.01.008. Epub 2021 Jan 27. Transl Res. 2021. PMID: 33515780 Free PMC article.
Peripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models.
Costa-Machado LF, Garcia-Dominguez E, McIntyre RL, Lopez-Aceituno JL, Ballesteros-Gonzalez Á, Tapia-Gonzalez A, Fabregat-Safont D, Eisenberg T, Gomez J, Plaza A, Sierra-Ramirez A, Perez M, Villanueva-Bermejo D, Fornari T, Loza MI, Herradon G, Hofer SJ, Magnes C, Madeo F, Duerr JS, Pozo OJ, Galindo MI, Del Pino I, Houtkooper RH, Megias D, Viña J, Gomez-Cabrera MC, Fernandez-Marcos PJ. Costa-Machado LF, et al. Among authors: fernandez marcos pj. Nat Commun. 2023 May 15;14(1):2779. doi: 10.1038/s41467-023-38410-y. Nat Commun. 2023. PMID: 37188705 Free PMC article.
Pharmacological and genetic increases in liver NADPH levels ameliorate NASH progression in female mice.
Rodriguez-Ramiro I, Pastor-Fernández A, López-Aceituno JL, Garcia-Dominguez E, Sierra-Ramirez A, Valverde AM, Martinez-Pastor B, Efeyan A, Gomez-Cabrera MC, Viña J, Fernandez-Marcos PJ. Rodriguez-Ramiro I, et al. Among authors: fernandez marcos pj. Free Radic Biol Med. 2024 Jan;210:448-461. doi: 10.1016/j.freeradbiomed.2023.11.019. Epub 2023 Nov 29. Free Radic Biol Med. 2024. PMID: 38036067 Free article.
54 results