Agrawal NJ - Search Results

1

Engineered IL-21 Cytokine Muteins Fused to Anti-PD-1 Antibodies Can Improve CD8+ T Cell Function and Anti-tumor Immunity.

Shen S, Sckisel G, Sahoo A, Lalani A, Otter DD, Pearson J, DeVoss J, Cheng J, Casey SC, Case R, Yang M, Low R, Daris M, Fan B, Agrawal NJ, Ali K. Shen S, et al. Among authors: agrawal nj. Front Immunol. 2020 May 8;11:832. doi: 10.3389/fimmu.2020.00832. eCollection 2020. Front Immunol. 2020. PMID: 32457754 Free PMC article.

2

Culture temperature modulates half antibody and aggregate formation in a Chinese hamster ovary cell line expressing a bispecific antibody.

Gomez N, Wieczorek A, Lu F, Bruno R, Diaz L, Agrawal NJ, Daris K. Gomez N, et al. Among authors: agrawal nj. Biotechnol Bioeng. 2018 Dec;115(12):2930-2940. doi: 10.1002/bit.26803. Epub 2018 Oct 5. Biotechnol Bioeng. 2018. PMID: 30036451

3

Heterogeneity in Disulfide Bond Reduction in IgG1 Antibodies Is Governed by Solvent Accessibility of the Cysteines.

Natesan R, Dykstra AB, Banerjee A, Agrawal NJ. Natesan R, et al. Among authors: agrawal nj. Antibodies (Basel). 2023 Dec 13;12(4):83. doi: 10.3390/antib12040083. Antibodies (Basel). 2023. PMID: 38131805 Free PMC article.

4

IgG1 and IgG4 antibodies sample initial structure dependent local conformational states and exhibit non-identical Fab dynamics.

Natesan R, Agrawal NJ. Natesan R, et al. Among authors: agrawal nj. Sci Rep. 2023 Mar 23;13(1):4791. doi: 10.1038/s41598-023-32067-9. Sci Rep. 2023. PMID: 36959284 Free PMC article.

5

Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody.

Natesan R, Agrawal NJ. Natesan R, et al. Among authors: agrawal nj. Sci Rep. 2022 Jun 4;12(1):9321. doi: 10.1038/s41598-022-13370-3. Sci Rep. 2022. PMID: 35661134 Free PMC article.

6

Tank Binding Kinase 1 modulates spindle assembly checkpoint components to regulate mitosis in breast and lung cancer cells.

Maan M, Agrawal NJ, Padmanabhan J, Leitzinger CC, Rivera-Rivera Y, Saavedra HI, Chellappan SP. Maan M, et al. Among authors: agrawal nj. Biochim Biophys Acta Mol Cell Res. 2021 Mar;1868(3):118929. doi: 10.1016/j.bbamcr.2020.118929. Epub 2020 Dec 11. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33310066 Free PMC article.

7

Tryptophan Oxidation of a Monoclonal Antibody Under Diverse Oxidative Stress Conditions: Distinct Oxidative Pathways Favor Specific Tryptophan Residues.

Jacobitz AW, Liu Q, Suravajjala S, Agrawal NJ. Jacobitz AW, et al. Among authors: agrawal nj. J Pharm Sci. 2021 Feb;110(2):719-726. doi: 10.1016/j.xphs.2020.10.039. Epub 2020 Oct 23. J Pharm Sci. 2021. PMID: 33198947

8

Effects of Buffer Composition on Site-Specific Glycation of Lysine Residues in Monoclonal Antibodies.

Jacobitz AW, Dykstra AB, Spahr C, Agrawal NJ. Jacobitz AW, et al. Among authors: agrawal nj. J Pharm Sci. 2020 Jan;109(1):293-300. doi: 10.1016/j.xphs.2019.05.025. Epub 2019 May 29. J Pharm Sci. 2020. PMID: 31150698

9

Prediction of the Hydrogen Peroxide-Induced Methionine Oxidation Propensity in Monoclonal Antibodies.

Agrawal NJ, Dykstra A, Yang J, Yue H, Nguyen X, Kolvenbach C, Angell N. Agrawal NJ, et al. J Pharm Sci. 2018 May;107(5):1282-1289. doi: 10.1016/j.xphs.2018.01.002. Epub 2018 Jan 8. J Pharm Sci. 2018. PMID: 29325924

10

Rational design of therapeutic mAbs against aggregation through protein engineering and incorporation of glycosylation motifs applied to bevacizumab.

Courtois F, Agrawal NJ, Lauer TM, Trout BL. Courtois F, et al. Among authors: agrawal nj. MAbs. 2016;8(1):99-112. doi: 10.1080/19420862.2015.1112477. MAbs. 2016. PMID: 26514585 Free PMC article.

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