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Page 1
Nucleotide depletion reveals the impaired ribosome biogenesis checkpoint as a barrier against DNA damage.
Pelletier J, Riaño-Canalias F, Almacellas E, Mauvezin C, Samino S, Feu S, Menoyo S, Domostegui A, Garcia-Cajide M, Salazar R, Cortés C, Marcos R, Tauler A, Yanes O, Agell N, Kozma SC, Gentilella A, Thomas G. Pelletier J, et al. Among authors: domostegui a. EMBO J. 2020 Jul 1;39(13):e103838. doi: 10.15252/embj.2019103838. Epub 2020 Jun 2. EMBO J. 2020. PMID: 32484960 Free PMC article.
Impaired ribosome biogenesis checkpoint activation induces p53-dependent MCL-1 degradation and MYC-driven lymphoma death.
Domostegui A, Peddigari S, Mercer CA, Iannizzotto F, Rodriguez ML, Garcia-Cajide M, Amador V, Diepstraten ST, Kelly GL, Salazar R, Kozma SC, Kusnadi EP, Kang J, Gentilella A, Pearson RB, Thomas G, Pelletier J. Domostegui A, et al. Blood. 2021 Jun 17;137(24):3351-3364. doi: 10.1182/blood.2020007452. Blood. 2021. PMID: 33512431 Free PMC article.
Chasing molecular glue degraders: screening approaches.
Domostegui A, Nieto-Barrado L, Perez-Lopez C, Mayor-Ruiz C. Domostegui A, et al. Chem Soc Rev. 2022 Jul 4;51(13):5498-5517. doi: 10.1039/d2cs00197g. Chem Soc Rev. 2022. PMID: 35723413 Review.