Marshall JR - Search Results

1

Synthesis of protected 3-aminopiperidine and 3-aminoazepane derivatives using enzyme cascades.

Ford GJ , Kress N , Mattey AP , Hepworth LJ , Baldwin CR , Marshall JR , Seibt LS , Huang M , Birmingham WR , Turner NJ , Flitsch SL . Ford GJ , et al. Among authors: marshall jr. Chem Commun (Camb). 2020 Jul 21;56(57):7949-7952. doi: 10.1039/d0cc02976a. Epub 2020 Jun 12. Chem Commun (Camb). 2020. PMID: 32531011

2

Chemoenzymatic Synthesis of Substituted Azepanes by Sequential Biocatalytic Reduction and Organolithium-Mediated Rearrangement.

Zawodny W, Montgomery SL, Marshall JR, Finnigan JD, Turner NJ, Clayden J. Zawodny W, et al. Among authors: marshall jr. J Am Chem Soc. 2018 Dec 26;140(51):17872-17877. doi: 10.1021/jacs.8b11891. Epub 2018 Dec 14. J Am Chem Soc. 2018. PMID: 30521324

3

One-Pot Biocatalytic Cascade Reduction of Cyclic Enimines for the Preparation of Diastereomerically Enriched N-Heterocycles.

Thorpe TW, France SP, Hussain S, Marshall JR, Zawodny W, Mangas-Sanchez J, Montgomery SL, Howard RM, Daniels DSB, Kumar R, Parmeggiani F, Turner NJ. Thorpe TW, et al. Among authors: marshall jr. J Am Chem Soc. 2019 Dec 11;141(49):19208-19213. doi: 10.1021/jacs.9b10053. Epub 2019 Nov 26. J Am Chem Soc. 2019. PMID: 31743008

4

Characterization of imine reductases in reductive amination for the exploration of structure-activity relationships.

Montgomery SL, Pushpanath A, Heath RS, Marshall JR, Klemstein U, Galman JL, Woodlock D, Bisagni S, Taylor CJ, Mangas-Sanchez J, Ramsden JI, Dominguez B, Turner NJ. Montgomery SL, et al. Among authors: marshall jr. Sci Adv. 2020 May 22;6(21):eaay9320. doi: 10.1126/sciadv.aay9320. eCollection 2020 May. Sci Adv. 2020. PMID: 32494734 Free PMC article.

5

Screening and characterization of a diverse panel of metagenomic imine reductases for biocatalytic reductive amination.

Marshall JR, Yao P, Montgomery SL, Finnigan JD, Thorpe TW, Palmer RB, Mangas-Sanchez J, Duncan RAM, Heath RS, Graham KM, Cook DJ, Charnock SJ, Turner NJ. Marshall JR, et al. Nat Chem. 2021 Feb;13(2):140-148. doi: 10.1038/s41557-020-00606-w. Epub 2020 Dec 30. Nat Chem. 2021. PMID: 33380742 Free PMC article.

6

Asymmetric Synthesis of N-Substituted α-Amino Esters from α-Ketoesters via Imine Reductase-Catalyzed Reductive Amination.

Yao P, Marshall JR, Xu Z, Lim J, Charnock SJ, Zhu D, Turner NJ. Yao P, et al. Among authors: marshall jr. Angew Chem Int Ed Engl. 2021 Apr 12;60(16):8717-8721. doi: 10.1002/anie.202016589. Epub 2021 Mar 9. Angew Chem Int Ed Engl. 2021. PMID: 33555620 Free PMC article.

7

Development of Continuous Flow Systems to Access Secondary Amines Through Previously Incompatible Biocatalytic Cascades*.

Mattey AP, Ford GJ, Citoler J, Baldwin C, Marshall JR, Palmer RB, Thompson M, Turner NJ, Cosgrove SC, Flitsch SL. Mattey AP, et al. Among authors: marshall jr. Angew Chem Int Ed Engl. 2021 Aug 16;60(34):18660-18665. doi: 10.1002/anie.202103805. Epub 2021 May 19. Angew Chem Int Ed Engl. 2021. PMID: 33856106 Free PMC article.

8

Rapid Screening of Diverse Biotransformations for Enzyme Evolution.

Kempa EE, Galman JL, Parmeggiani F, Marshall JR, Malassis J, Fontenelle CQ, Vendeville JB, Linclau B, Charnock SJ, Flitsch SL, Turner NJ, Barran PE. Kempa EE, et al. Among authors: marshall jr. JACS Au. 2021 Apr 26;1(4):508-516. doi: 10.1021/jacsau.1c00027. Epub 2021 Apr 8. JACS Au. 2021. PMID: 34056634 Free PMC article.

9

Asymmetric synthesis of primary amines catalyzed by thermotolerant fungal reductive aminases.

Mangas-Sanchez J, Sharma M, Cosgrove SC, Ramsden JI, Marshall JR, Thorpe TW, Palmer RB, Grogan G, Turner NJ. Mangas-Sanchez J, et al. Among authors: marshall jr. Chem Sci. 2020 May 5;11(19):5052-5057. doi: 10.1039/d0sc02253e. Chem Sci. 2020. PMID: 34122962 Free PMC article.

10

Synthesis of Pharmaceutically Relevant 2-Aminotetralin and 3-Aminochroman Derivatives via Enzymatic Reductive Amination.

Citoler J, Harawa V, Marshall JR, Bevinakatti H, Finnigan JD, Charnock SJ, Turner NJ. Citoler J, et al. Among authors: marshall jr. Angew Chem Int Ed Engl. 2021 Nov 8;60(46):24456-24460. doi: 10.1002/anie.202110321. Epub 2021 Oct 12. Angew Chem Int Ed Engl. 2021. PMID: 34478225

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