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Page 1
Potent neutralizing antibodies from COVID-19 patients define multiple targets of vulnerability.
Brouwer PJM, Caniels TG, van der Straten K, Snitselaar JL, Aldon Y, Bangaru S, Torres JL, Okba NMA, Claireaux M, Kerster G, Bentlage AEH, van Haaren MM, Guerra D, Burger JA, Schermer EE, Verheul KD, van der Velde N, van der Kooi A, van Schooten J, van Breemen MJ, Bijl TPL, Sliepen K, Aartse A, Derking R, Bontjer I, Kootstra NA, Wiersinga WJ, Vidarsson G, Haagmans BL, Ward AB, de Bree GJ, Sanders RW, van Gils MJ. Brouwer PJM, et al. Science. 2020 Aug 7;369(6504):643-650. doi: 10.1126/science.abc5902. Epub 2020 Jun 15. Science. 2020. PMID: 32540902 Free PMC article.
Structure and immunogenicity of a stabilized HIV-1 envelope trimer based on a group-M consensus sequence.
Sliepen K, Han BW, Bontjer I, Mooij P, Garces F, Behrens AJ, Rantalainen K, Kumar S, Sarkar A, Brouwer PJM, Hua Y, Tolazzi M, Schermer E, Torres JL, Ozorowski G, van der Woude P, de la Peña AT, van Breemen MJ, Camacho-Sánchez JM, Burger JA, Medina-Ramírez M, González N, Alcami J, LaBranche C, Scarlatti G, van Gils MJ, Crispin M, Montefiori DC, Ward AB, Koopman G, Moore JP, Shattock RJ, Bogers WM, Wilson IA, Sanders RW. Sliepen K, et al. Among authors: brouwer pjm. Nat Commun. 2019 May 29;10(1):2355. doi: 10.1038/s41467-019-10262-5. Nat Commun. 2019. PMID: 31142746 Free PMC article.
Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle.
Brouwer PJM, Antanasijevic A, Berndsen Z, Yasmeen A, Fiala B, Bijl TPL, Bontjer I, Bale JB, Sheffler W, Allen JD, Schorcht A, Burger JA, Camacho M, Ellis D, Cottrell CA, Behrens AJ, Catalano M, Del Moral-Sánchez I, Ketas TJ, LaBranche C, van Gils MJ, Sliepen K, Stewart LJ, Crispin M, Montefiori DC, Baker D, Moore JP, Klasse PJ, Ward AB, King NP, Sanders RW. Brouwer PJM, et al. Nat Commun. 2019 Sep 19;10(1):4272. doi: 10.1038/s41467-019-12080-1. Nat Commun. 2019. PMID: 31537780 Free PMC article.
An alternative binding mode of IGHV3-53 antibodies to the SARS-CoV-2 receptor binding domain.
Wu NC, Yuan M, Liu H, Lee CD, Zhu X, Bangaru S, Torres JL, Caniels TG, Brouwer PJM, van Gils MJ, Sanders RW, Ward AB, Wilson IA. Wu NC, et al. Among authors: brouwer pjm. bioRxiv [Preprint]. 2020 Jul 27:2020.07.26.222232. doi: 10.1101/2020.07.26.222232. bioRxiv. 2020. Update in: Cell Rep. 2020 Oct 20;33(3):108274. doi: 10.1016/j.celrep.2020.108274 PMID: 32743580 Free PMC article. Updated. Preprint.
Tailored design of protein nanoparticle scaffolds for multivalent presentation of viral glycoprotein antigens.
Ueda G, Antanasijevic A, Fallas JA, Sheffler W, Copps J, Ellis D, Hutchinson GB, Moyer A, Yasmeen A, Tsybovsky Y, Park YJ, Bick MJ, Sankaran B, Gillespie RA, Brouwer PJ, Zwart PH, Veesler D, Kanekiyo M, Graham BS, Sanders RW, Moore JP, Klasse PJ, Ward AB, King NP, Baker D. Ueda G, et al. Elife. 2020 Aug 4;9:e57659. doi: 10.7554/eLife.57659. Elife. 2020. PMID: 32748788 Free PMC article.
Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens.
Antanasijevic A, Ueda G, Brouwer PJM, Copps J, Huang D, Allen JD, Cottrell CA, Yasmeen A, Sewall LM, Bontjer I, Ketas TJ, Turner HL, Berndsen ZT, Montefiori DC, Klasse PJ, Crispin M, Nemazee D, Moore JP, Sanders RW, King NP, Baker D, Ward AB. Antanasijevic A, et al. Among authors: brouwer pjm. PLoS Pathog. 2020 Aug 11;16(8):e1008665. doi: 10.1371/journal.ppat.1008665. eCollection 2020 Aug. PLoS Pathog. 2020. PMID: 32780770 Free PMC article.
Cross-neutralization of a SARS-CoV-2 antibody to a functionally conserved site is mediated by avidity.
Liu H, Wu NC, Yuan M, Bangaru S, Torres JL, Caniels TG, van Schooten J, Zhu X, Lee CD, Brouwer PJM, van Gils MJ, Sanders RW, Ward AB, Wilson IA. Liu H, et al. Among authors: brouwer pjm. bioRxiv [Preprint]. 2020 Aug 3:2020.08.02.233536. doi: 10.1101/2020.08.02.233536. bioRxiv. 2020. Update in: Immunity. 2020 Dec 15;53(6):1272-1280.e5. doi: 10.1016/j.immuni.2020.10.023 PMID: 32793906 Free PMC article. Updated. Preprint.
Comparative assessment of multiple COVID-19 serological technologies supports continued evaluation of point-of-care lateral flow assays in hospital and community healthcare settings.
Pickering S, Betancor G, Galão RP, Merrick B, Signell AW, Wilson HD, Kia Ik MT, Seow J, Graham C, Acors S, Kouphou N, Steel KJA, Hemmings O, Patel A, Nebbia G, Douthwaite S, O'Connell L, Luptak J, McCoy LE, Brouwer P, van Gils MJ, Sanders RW, Martinez Nunez R, Bisnauthsing K, O'Hara G, MacMahon E, Batra R, Malim MH, Neil SJD, Doores KJ, Edgeworth JD. Pickering S, et al. PLoS Pathog. 2020 Sep 24;16(9):e1008817. doi: 10.1371/journal.ppat.1008817. eCollection 2020 Sep. PLoS Pathog. 2020. PMID: 32970782 Free PMC article.
43 results