Leask A - Search Results

1

Epithelial Vasopressin Type-2 Receptors Regulate Myofibroblasts by a YAP-CCN2-Dependent Mechanism in Polycystic Kidney Disease.

Dwivedi N, Tao S, Jamadar A, Sinha S, Howard C, Wallace DP, Fields TA, Leask A, Calvet JP, Rao R. Dwivedi N, et al. Among authors: leask a. J Am Soc Nephrol. 2020 Aug;31(8):1697-1710. doi: 10.1681/ASN.2020020190. Epub 2020 Jun 17. J Am Soc Nephrol. 2020. PMID: 32554753 Free PMC article.

2

CCN2 in Skin Fibrosis.

Leask A. Leask A. Methods Mol Biol. 2017;1489:417-421. doi: 10.1007/978-1-4939-6430-7_34. Methods Mol Biol. 2017. PMID: 27734393

3

Ccn2 Deletion Reduces Cardiac Dysfunction, Oxidative Markers, and Fibrosis Induced by Doxorubicin Administration in Mice.

Tejera-Muñoz A, Cortés M, Rodriguez-Rodriguez A, Tejedor-Santamaria L, Marchant V, Rayego-Mateos S, Gimeno-Longas MJ, Leask A, Nguyen TQ, Martín M, Tuñón J, Rodríguez I, Ruiz-Ortega M, Rodrigues-Díez RR. Tejera-Muñoz A, et al. Among authors: leask a. Int J Mol Sci. 2024 Sep 5;25(17):9617. doi: 10.3390/ijms25179617. Int J Mol Sci. 2024. PMID: 39273564 Free PMC article.

4

CCN2 is required for bleomycin-induced skin fibrosis in mice.

Liu S, Shi-wen X, Abraham DJ, Leask A. Liu S, et al. Among authors: leask a. Arthritis Rheum. 2011 Jan;63(1):239-46. doi: 10.1002/art.30074. Arthritis Rheum. 2011. PMID: 20936632 Free article.

5

Mechanical tension increases CCN2/CTGF expression and proliferation in gingival fibroblasts via a TGFβ-dependent mechanism.

Guo F, Carter DE, Leask A. Guo F, et al. Among authors: leask a. PLoS One. 2011;6(5):e19756. doi: 10.1371/journal.pone.0019756. Epub 2011 May 17. PLoS One. 2011. PMID: 21611193 Free PMC article.

6

CCN2: a novel, specific and valid target for anti-fibrotic drug intervention.

Leask A. Leask A. Expert Opin Ther Targets. 2013 Sep;17(9):1067-71. doi: 10.1517/14728222.2013.812074. Epub 2013 Jul 13. Expert Opin Ther Targets. 2013. PMID: 23848501 Review.

7

Fibrosis caused by loss of PTEN expression in mouse fibroblasts is crucially dependent on CCN2.

Liu S, Parapuram SK, Leask A. Liu S, et al. Among authors: leask a. Arthritis Rheum. 2013 Nov;65(11):2940-4. doi: 10.1002/art.38121. Arthritis Rheum. 2013. PMID: 23983074 Free article.

8

CCN2 expression by fibroblasts is not required for cutaneous tissue repair.

Liu S, Thompson K, Leask A. Liu S, et al. Among authors: leask a. Wound Repair Regen. 2014 Jan-Feb;22(1):119-24. doi: 10.1111/wrr.12131. Wound Repair Regen. 2014. PMID: 24393160

9

Loss of PTEN expression by mouse fibroblasts results in lung fibrosis through a CCN2-dependent mechanism.

Parapuram SK, Thompson K, Tsang M, Hutchenreuther J, Bekking C, Liu S, Leask A. Parapuram SK, et al. Among authors: leask a. Matrix Biol. 2015 Apr;43:35-41. doi: 10.1016/j.matbio.2015.01.017. Epub 2015 Jan 30. Matrix Biol. 2015. PMID: 25644104

10

Genetic manipulation of CCN2/CTGF unveils cell-specific ECM-remodeling effects in injured skeletal muscle.

Petrosino JM, Leask A, Accornero F. Petrosino JM, et al. Among authors: leask a. FASEB J. 2019 Feb;33(2):2047-2057. doi: 10.1096/fj.201800622RR. Epub 2018 Sep 14. FASEB J. 2019. PMID: 30216109 Free PMC article.

To address this question, a conditional Ctgf myofiber and fibroblast-knockout mouse lines were generated and crossed to a dystrophic background. ...Our results show that the myofibers are critical mediators of the deleterious effects associated with CTGF in MD and a …

To address this question, a conditional Ctgf myofiber and fibroblast-knockout mouse lines were generated and crossed to a dyst …

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