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Multiplexing DNA methylation markers to detect circulating cell-free DNA derived from human pancreatic β cells.
Neiman D, Gillis D, Piyanzin S, Cohen D, Fridlich O, Moss J, Zick A, Oron T, Sundberg F, Forsander G, Skog O, Korsgren O, Levy-Khademi F, Arbel D, Hashavia S, Shapiro AMJ, Speake C, Greenbaum C, Hosford J, Posgai A, Atkinson MA, Glaser B, Schatz DA, Shemer R, Dor Y. Neiman D, et al. Among authors: shapiro amj. JCI Insight. 2020 Jul 23;5(14):e136579. doi: 10.1172/jci.insight.136579. JCI Insight. 2020. PMID: 32573495 Free PMC article.
Are stem cells a cure for diabetes?
McCall MD, Toso C, Baetge EE, Shapiro AM. McCall MD, et al. Clin Sci (Lond). 2009 Oct 12;118(2):87-97. doi: 10.1042/CS20090072. Clin Sci (Lond). 2009. PMID: 19807695 Review.
p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.
Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I. Helman A, et al. Nat Med. 2016 Apr;22(4):412-20. doi: 10.1038/nm.4054. Epub 2016 Mar 7. Nat Med. 2016. PMID: 26950362 Free PMC article.
Identification of tissue-specific cell death using methylation patterns of circulating DNA.
Lehmann-Werman R, Neiman D, Zemmour H, Moss J, Magenheim J, Vaknin-Dembinsky A, Rubertsson S, Nellgård B, Blennow K, Zetterberg H, Spalding K, Haller MJ, Wasserfall CH, Schatz DA, Greenbaum CJ, Dorrell C, Grompe M, Zick A, Hubert A, Maoz M, Fendrich V, Bartsch DK, Golan T, Ben Sasson SA, Zamir G, Razin A, Cedar H, Shapiro AM, Glaser B, Shemer R, Dor Y. Lehmann-Werman R, et al. Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):E1826-34. doi: 10.1073/pnas.1519286113. Epub 2016 Mar 14. Proc Natl Acad Sci U S A. 2016. PMID: 26976580 Free PMC article.
Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type-specific methylation in enhancers.
Neiman D, Moss J, Hecht M, Magenheim J, Piyanzin S, Shapiro AMJ, de Koning EJP, Razin A, Cedar H, Shemer R, Dor Y. Neiman D, et al. Among authors: shapiro amj. Proc Natl Acad Sci U S A. 2017 Dec 19;114(51):13525-13530. doi: 10.1073/pnas.1713736114. Epub 2017 Dec 4. Proc Natl Acad Sci U S A. 2017. PMID: 29203669 Free PMC article.
Beta Cell Death by Cell-free DNA and Outcome After Clinical Islet Transplantation.
Gala-Lopez BL, Neiman D, Kin T, O'Gorman D, Pepper AR, Malcolm AJ, Pianzin S, Senior PA, Campbell P, Glaser B, Dor Y, Shemer R, Shapiro AMJ. Gala-Lopez BL, et al. Among authors: shapiro amj. Transplantation. 2018 Jun;102(6):978-985. doi: 10.1097/TP.0000000000002083. Transplantation. 2018. PMID: 29329189
Postnatal Exocrine Pancreas Growth by Cellular Hypertrophy Correlates with a Shorter Lifespan in Mammals.
Anzi S, Stolovich-Rain M, Klochendler A, Fridlich O, Helman A, Paz-Sonnenfeld A, Avni-Magen N, Kaufman E, Ginzberg MB, Snider D, Ray S, Brecht M, Holmes MM, Meir K, Avivi A, Shams I, Berkowitz A, Shapiro AMJ, Glaser B, Ben-Sasson S, Kafri R, Dor Y. Anzi S, et al. Among authors: shapiro amj. Dev Cell. 2018 Jun 18;45(6):726-737.e3. doi: 10.1016/j.devcel.2018.05.024. Dev Cell. 2018. PMID: 29920277 Free article.
362 results