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Repositioning of leishmanicidal [1,2,3]Triazolo[1,5-a]pyridinium salts for Chagas disease treatment: Trypanosoma cruzi cell death involving mitochondrial membrane depolarisation and Fe-SOD inhibition.
Martín-Escolano R, Martín-Escolano J, Ballesteros-Garrido R, Cirauqui N, Abarca B, Rosales MJ, Sánchez-Moreno M, Ballesteros R, Marín C. Martín-Escolano R, et al. Among authors: cirauqui n. Parasitol Res. 2020 Sep;119(9):2943-2954. doi: 10.1007/s00436-020-06779-0. Epub 2020 Jul 1. Parasitol Res. 2020. PMID: 32607710
In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.
Moreno-Viguri E, Jiménez-Montes C, Martín-Escolano R, Santivañez-Veliz M, Martin-Montes A, Azqueta A, Jimenez-Lopez M, Zamora Ledesma S, Cirauqui N, López de Ceráin A, Marín C, Sánchez-Moreno M, Pérez-Silanes S. Moreno-Viguri E, et al. Among authors: cirauqui n. J Med Chem. 2016 Dec 22;59(24):10929-10945. doi: 10.1021/acs.jmedchem.6b00784. Epub 2016 Dec 6. J Med Chem. 2016. PMID: 28002965 Free article.
Correction to In Vitro and in Vivo Anti-Trypanosoma cruzi Activity of New Arylamine Mannich Base-Type Derivatives.
Moreno-Viguri E, Jiménez-Montes C, Martín-Escolano R, Santivañez-Veliz M, Martin-Montes A, Azqueta A, Jimenez-Lopez M, Zamora Ledesma S, Cirauqui N, López de Ceráin A, Marín C, Sánchez-Moreno M, Pérez-Silanes S. Moreno-Viguri E, et al. Among authors: cirauqui n. J Med Chem. 2017 Mar 23;60(6):2604. doi: 10.1021/acs.jmedchem.7b00263. Epub 2017 Mar 3. J Med Chem. 2017. PMID: 28257207 No abstract available.
Second Generation of Mannich Base-Type Derivatives with in Vivo Activity against Trypanosoma cruzi.
Martín-Escolano R, Moreno-Viguri E, Santivañez-Veliz M, Martin-Montes A, Medina-Carmona E, Paucar R, Marín C, Azqueta A, Cirauqui N, Pey AL, Pérez-Silanes S, Sánchez-Moreno M. Martín-Escolano R, et al. Among authors: cirauqui n. J Med Chem. 2018 Jul 12;61(13):5643-5663. doi: 10.1021/acs.jmedchem.8b00468. Epub 2018 Jun 22. J Med Chem. 2018. PMID: 29883536
A step towards development of promising trypanocidal agents: Synthesis, characterization and in vitro biological evaluation of ferrocenyl Mannich base-type derivatives.
Paucar R, Martín-Escolano R, Moreno-Viguri E, Cirauqui N, Rodrigues CR, Marín C, Sánchez-Moreno M, Pérez-Silanes S, Ravera M, Gabano E. Paucar R, et al. Among authors: cirauqui n. Eur J Med Chem. 2019 Feb 1;163:569-582. doi: 10.1016/j.ejmech.2018.12.005. Epub 2018 Dec 4. Eur J Med Chem. 2019. PMID: 30554132
In Vivo Biological Evaluation of a Synthetic Royleanone Derivative as a Promising Fast-Acting Trypanocidal Agent by Inducing Mitochondrial-Dependent Necrosis.
Martín-Escolano R, Guardia JJ, Martín-Escolano J, Cirauqui N, Fernández A, Rosales MJ, Chahboun R, Sánchez-Moreno M, Alvarez-Manzaneda E, Marín C. Martín-Escolano R, et al. Among authors: cirauqui n. J Nat Prod. 2020 Dec 24;83(12):3571-3583. doi: 10.1021/acs.jnatprod.0c00651. Epub 2020 Nov 30. J Nat Prod. 2020. PMID: 33253573
Identification of Aryl Polyamines Derivatives as Anti-Trypanosoma cruzi Agents Targeting Iron Superoxide Dismutase.
Martín-Escolano R, Molina-Carreño D, Martín-Escolano J, Clares MP, Galiana-Roselló C, González-García J, Cirauqui N, Llinares JM, Rosales MJ, García-España E, Marín C. Martín-Escolano R, et al. Among authors: cirauqui n. Pharmaceutics. 2022 Dec 31;15(1):140. doi: 10.3390/pharmaceutics15010140. Pharmaceutics. 2022. PMID: 36678771 Free PMC article.
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