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Infantile Pain Episodes Associated with Novel Nav1.9 Mutations in Familial Episodic Pain Syndrome in Japanese Families.
Okuda H, Noguchi A, Kobayashi H, Kondo D, Harada KH, Youssefian S, Shioi H, Kabata R, Domon Y, Kubota K, Kitano Y, Takayama Y, Hitomi T, Ohno K, Saito Y, Asano T, Tominaga M, Takahashi T, Koizumi A. Okuda H, et al. Among authors: kubota k. PLoS One. 2016 May 25;11(5):e0154827. doi: 10.1371/journal.pone.0154827. eCollection 2016. PLoS One. 2016. PMID: 27224030 Free PMC article. Clinical Trial.
Anxiolytic-like effects of mirogabalin, a novel ligand for α2δ ligand of voltage-gated calcium channels, in rats repeatedly injected with acidic saline intramuscularly, as an experimental model of fibromyalgia.
Murasawa H, Kobayashi H, Yasuda SI, Saeki K, Domon Y, Arakawa N, Kubota K, Kitano Y. Murasawa H, et al. Among authors: kubota k. Pharmacol Rep. 2020 Jun;72(3):571-579. doi: 10.1007/s43440-020-00103-4. Epub 2020 Apr 8. Pharmacol Rep. 2020. PMID: 32270470
Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor.
Shinozuka T, Kobayashi H, Suzuki S, Tanaka K, Karanjule N, Hayashi N, Tsuda T, Tokumaru E, Inoue M, Ueda K, Kimoto H, Domon Y, Takahashi S, Kubota K, Yokoyama T, Shimizugawa A, Koishi R, Fujiwara C, Asano D, Sakakura T, Takasuna K, Abe Y, Watanabe T, Kitano Y. Shinozuka T, et al. Among authors: kubota k. J Med Chem. 2020 Sep 24;63(18):10204-10220. doi: 10.1021/acs.jmedchem.0c00259. Epub 2020 May 26. J Med Chem. 2020. PMID: 32392056
A novel [5.2.1]bicyclic amine is a potent analgesic without µ opioid activity.
Noguchi T, Umezaki Y, Takano R, Fujimoto T, Domon Y, Kubota K, Ueda K, Kawase Y, Yabe K, Yokoyama M, Shimada K. Noguchi T, et al. Among authors: kubota k. Bioorg Med Chem Lett. 2021 Mar 15;36:127790. doi: 10.1016/j.bmcl.2021.127790. Epub 2021 Jan 14. Bioorg Med Chem Lett. 2021. PMID: 33454387
3,670 results