Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

153 results

Filters applied: . Clear all
Results are displayed in a computed author sort order. The Publication Date timeline is not available.
Page 1
Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor.
Shinozuka T, Kobayashi H, Suzuki S, Tanaka K, Karanjule N, Hayashi N, Tsuda T, Tokumaru E, Inoue M, Ueda K, Kimoto H, Domon Y, Takahashi S, Kubota K, Yokoyama T, Shimizugawa A, Koishi R, Fujiwara C, Asano D, Sakakura T, Takasuna K, Abe Y, Watanabe T, Kitano Y. Shinozuka T, et al. J Med Chem. 2020 Sep 24;63(18):10204-10220. doi: 10.1021/acs.jmedchem.0c00259. Epub 2020 May 26. J Med Chem. 2020. PMID: 32392056
Discovery of a Novel Class of ERRα Agonists.
Shinozuka T, Ito S, Kimura T, Izumi M, Wakabayashi K. Shinozuka T, et al. ACS Med Chem Lett. 2021 Apr 21;12(5):817-821. doi: 10.1021/acsmedchemlett.1c00100. eCollection 2021 May 13. ACS Med Chem Lett. 2021. PMID: 34055231 Free PMC article.
CYP2C8-Mediated Formation of a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Cytochrome P450 and Aldehyde Oxidase Substrate.
Asano D, Hamaue S, Zahir H, Shiozawa H, Nishiya Y, Kimura T, Kazui M, Yamamura N, Ikeguchi M, Shibayama T, Inoue SI, Shinozuka T, Watanabe T, Yahara C, Watanabe N, Yoshinari K. Asano D, et al. Among authors: shinozuka t. Drug Metab Dispos. 2022 Mar;50(3):235-242. doi: 10.1124/dmd.121.000665. Epub 2021 Dec 20. Drug Metab Dispos. 2022. PMID: 34930785
Inhibition of NaV1.7: the possibility of ideal analgesics.
Kitano Y, Shinozuka T. Kitano Y, et al. Among authors: shinozuka t. RSC Med Chem. 2022 Aug 1;13(8):895-920. doi: 10.1039/d2md00081d. eCollection 2022 Aug 17. RSC Med Chem. 2022. PMID: 36092147 Free PMC article. Review.
Physiologically Based Pharmacokinetic Modeling for Quantitative Prediction of Exposure to a Human Disproportionate Metabolite of the Selective NaV1.7 Inhibitor DS-1971a, a Mixed Substrate of Cytochrome P450 and Aldehyde Oxidase, Using Chimeric Mice With Humanized Liver.
Asano D, Nakamura K, Nishiya Y, Shiozawa H, Takakusa H, Shibayama T, Inoue SI, Shinozuka T, Hamada T, Yahara C, Watanabe N, Yoshinari K. Asano D, et al. Among authors: shinozuka t. Drug Metab Dispos. 2023 Jan;51(1):67-80. doi: 10.1124/dmd.122.001000. Epub 2022 Oct 23. Drug Metab Dispos. 2023. PMID: 36273823
N-Aryl Indoles as a Novel Class of Potent NaV1.7 Inhibitors.
Karanjule N, Hayashi N, Suzuki S, Tsuda T, Tokumaru E, Tanaka K, Kimoto H, Domon Y, Takahashi S, Kubota K, Kitano Y, Yokoyama T, Koishi R, Fujiwara C, Inaba S, Asano D, Sakakura T, Takasuna K, Shinozuka T. Karanjule N, et al. Among authors: shinozuka t. ACS Med Chem Lett. 2023 May 24;14(6):788-793. doi: 10.1021/acsmedchemlett.3c00079. eCollection 2023 Jun 8. ACS Med Chem Lett. 2023. PMID: 37312847 Free PMC article.
153 results