Hung M - Search Results

1

Clinical targeting of HIV capsid protein with a long-acting small molecule.

Link JO, Rhee MS, Tse WC, Zheng J, Somoza JR, Rowe W, Begley R, Chiu A, Mulato A, Hansen D, Singer E, Tsai LK, Bam RA, Chou CH, Canales E, Brizgys G, Zhang JR, Li J, Graupe M, Morganelli P, Liu Q, Wu Q, Halcomb RL, Saito RD, Schroeder SD, Lazerwith SE, Bondy S, Jin D, Hung M, Novikov N, Liu X, Villaseñor AG, Cannizzaro CE, Hu EY, Anderson RL, Appleby TC, Lu B, Mwangi J, Liclican A, Niedziela-Majka A, Papalia GA, Wong MH, Leavitt SA, Xu Y, Koditek D, Stepan GJ, Yu H, Pagratis N, Clancy S, Ahmadyar S, Cai TZ, Sellers S, Wolckenhauer SA, Ling J, Callebaut C, Margot N, Ram RR, Liu YP, Hyland R, Sinclair GI, Ruane PJ, Crofoot GE, McDonald CK, Brainard DM, Lad L, Swaminathan S, Sundquist WI, Sakowicz R, Chester AE, Lee WE, Daar ES, Yant SR, Cihlar T. Link JO, et al. Among authors: hung m. Nature. 2020 Aug;584(7822):614-618. doi: 10.1038/s41586-020-2443-1. Epub 2020 Jul 1. Nature. 2020. PMID: 32612233 Free PMC article. Clinical Trial.

2

HIV-1 integrase preassembled on donor DNA is refractory to activity stimulation by LEDGF/p75.

Yu F, Jones GS, Hung M, Wagner AH, MacArthur HL, Liu X, Leavitt S, McDermott MJ, Tsiang M. Yu F, et al. Among authors: hung m. Biochemistry. 2007 Mar 13;46(10):2899-908. doi: 10.1021/bi602387u. Epub 2007 Feb 14. Biochemistry. 2007. PMID: 17298035

3

The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.

Ly JK, Margot NA, MacArthur HL, Hung M, Miller MD, White KL. Ly JK, et al. Among authors: hung m. Antivir Chem Chemother. 2007;18(6):307-16. doi: 10.1177/095632020701800603. Antivir Chem Chemother. 2007. PMID: 18320935 Free article.

4

Modeling, analysis, and validation of a novel HIV integrase structure provide insights into the binding modes of potent integrase inhibitors.

Chen X, Tsiang M, Yu F, Hung M, Jones GS, Zeynalzadegan A, Qi X, Jin H, Kim CU, Swaminathan S, Chen JM. Chen X, et al. Among authors: hung m. J Mol Biol. 2008 Jul 11;380(3):504-19. doi: 10.1016/j.jmb.2008.04.054. Epub 2008 May 1. J Mol Biol. 2008. PMID: 18565342

5

Affinities between the binding partners of the HIV-1 integrase dimer-lens epithelium-derived growth factor (IN dimer-LEDGF) complex.

Tsiang M, Jones GS, Hung M, Mukund S, Han B, Liu X, Babaoglu K, Lansdon E, Chen X, Todd J, Cai T, Pagratis N, Sakowicz R, Geleziunas R. Tsiang M, et al. Among authors: hung m. J Biol Chem. 2009 Nov 27;284(48):33580-99. doi: 10.1074/jbc.M109.040121. Epub 2009 Sep 28. J Biol Chem. 2009. PMID: 19801648 Free PMC article.

6

Visualizing the molecular interactions of a nucleotide analog, GS-9148, with HIV-1 reverse transcriptase-DNA complex.

Lansdon EB, Samuel D, Lagpacan L, Brendza KM, White KL, Hung M, Liu X, Boojamra CG, Mackman RL, Cihlar T, Ray AS, McGrath ME, Swaminathan S. Lansdon EB, et al. Among authors: hung m. J Mol Biol. 2010 Apr 9;397(4):967-78. doi: 10.1016/j.jmb.2010.02.019. Epub 2010 Feb 13. J Mol Biol. 2010. PMID: 20156454

7

Crystal structures of HIV-1 reverse transcriptase with etravirine (TMC125) and rilpivirine (TMC278): implications for drug design.

Lansdon EB, Brendza KM, Hung M, Wang R, Mukund S, Jin D, Birkus G, Kutty N, Liu X. Lansdon EB, et al. Among authors: hung m. J Med Chem. 2010 May 27;53(10):4295-9. doi: 10.1021/jm1002233. J Med Chem. 2010. PMID: 20438081

8

The macroscopic rate of nucleic acid translocation by hepatitis C virus helicase NS3h is dependent on both sugar and base moieties.

Khaki AR, Field C, Malik S, Niedziela-Majka A, Leavitt SA, Wang R, Hung M, Sakowicz R, Brendza KM, Fischer CJ. Khaki AR, et al. Among authors: hung m. J Mol Biol. 2010 Jul 16;400(3):354-78. doi: 10.1016/j.jmb.2010.04.065. Epub 2010 May 6. J Mol Biol. 2010. PMID: 20451531 Free PMC article.

9

Dithiothreitol causes HIV-1 integrase dimer dissociation while agents interacting with the integrase dimer interface promote dimer formation.

Tsiang M, Jones GS, Hung M, Samuel D, Novikov N, Mukund S, Brendza KM, Niedziela-Majka A, Jin D, Liu X, Mitchell M, Sakowicz R, Geleziunas R. Tsiang M, et al. Among authors: hung m. Biochemistry. 2011 Mar 15;50(10):1567-81. doi: 10.1021/bi101504w. Epub 2011 Feb 21. Biochemistry. 2011. PMID: 21222490

10

Screening and identification of a novel class of TGF-β type 1 receptor kinase inhibitor.

Huynh QK, Wise SJ, Koch KA, Castonguay LA, Reid BG, Pagratis EE, Koditek D, Glascock CB, Pitts KR, Turner BA, Liu X, Hung M, Han B, Pagratis N. Huynh QK, et al. Among authors: hung m. J Biomol Screen. 2011 Aug;16(7):724-33. doi: 10.1177/1087057111405846. Epub 2011 Apr 26. J Biomol Screen. 2011. PMID: 21521800

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