Emperle M - Search Results

1

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.

Gao L, Emperle M, Guo Y, Grimm SA, Ren W, Adam S, Uryu H, Zhang ZM, Chen D, Yin J, Dukatz M, Anteneh H, Jurkowska RZ, Lu J, Wang Y, Bashtrykov P, Wade PA, Wang GG, Jeltsch A, Song J. Gao L, et al. Among authors: emperle m. Nat Commun. 2020 Jul 3;11(1):3355. doi: 10.1038/s41467-020-17109-4. Nat Commun. 2020. PMID: 32620778 Free PMC article.

2

Mechanistic Insights into Cytosine-N3 Methylation by DNA Methyltransferase DNMT3A.

Dukatz M, Requena CE, Emperle M, Hajkova P, Sarkies P, Jeltsch A. Dukatz M, et al. Among authors: emperle m. J Mol Biol. 2019 Aug 9;431(17):3139-3145. doi: 10.1016/j.jmb.2019.06.015. Epub 2019 Jun 21. J Mol Biol. 2019. PMID: 31229457 Free article.

3

Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns.

Emperle M, Adam S, Kunert S, Dukatz M, Baude A, Plass C, Rathert P, Bashtrykov P, Jeltsch A. Emperle M, et al. Nucleic Acids Res. 2019 Dec 2;47(21):11355-11367. doi: 10.1093/nar/gkz911. Nucleic Acids Res. 2019. PMID: 31620784 Free PMC article.

4

H3K36me2/3 Binding and DNA Binding of the DNA Methyltransferase DNMT3A PWWP Domain Both Contribute to its Chromatin Interaction.

Dukatz M, Holzer K, Choudalakis M, Emperle M, Lungu C, Bashtrykov P, Jeltsch A. Dukatz M, et al. Among authors: emperle m. J Mol Biol. 2019 Dec 6;431(24):5063-5074. doi: 10.1016/j.jmb.2019.09.006. Epub 2019 Oct 18. J Mol Biol. 2019. PMID: 31634469

5

Deep Enzymology Studies on DNA Methyltransferases Reveal Novel Connections between Flanking Sequences and Enzyme Activity.

Jeltsch A, Adam S, Dukatz M, Emperle M, Bashtrykov P. Jeltsch A, et al. Among authors: emperle m. J Mol Biol. 2021 Sep 17;433(19):167186. doi: 10.1016/j.jmb.2021.167186. Epub 2021 Aug 8. J Mol Biol. 2021. PMID: 34375615 Review.

6

Preferential Self-interaction of DNA Methyltransferase DNMT3A Subunits Containing the R882H Cancer Mutation Leads to Dominant Changes of Flanking Sequence Preferences.

Mack A, Emperle M, Schnee P, Adam S, Pleiss J, Bashtrykov P, Jeltsch A. Mack A, et al. Among authors: emperle m. J Mol Biol. 2022 Apr 15;434(7):167482. doi: 10.1016/j.jmb.2022.167482. Epub 2022 Feb 5. J Mol Biol. 2022. PMID: 35131259

7

The DNMT3A R882H mutation does not cause dominant negative effects in purified mixed DNMT3A/R882H complexes.

Emperle M, Dukatz M, Kunert S, Holzer K, Rajavelu A, Jurkowska RZ, Jeltsch A. Emperle M, et al. Sci Rep. 2018 Sep 5;8(1):13242. doi: 10.1038/s41598-018-31635-8. Sci Rep. 2018. PMID: 30185810 Free PMC article.

8

Cooperative DNA binding and protein/DNA fiber formation increases the activity of the Dnmt3a DNA methyltransferase.

Emperle M, Rajavelu A, Reinhardt R, Jurkowska RZ, Jeltsch A. Emperle M, et al. J Biol Chem. 2014 Oct 24;289(43):29602-13. doi: 10.1074/jbc.M114.572032. Epub 2014 Aug 21. J Biol Chem. 2014. PMID: 25147181 Free PMC article.

9

The DNMT3A R882H mutant displays altered flanking sequence preferences.

Emperle M, Rajavelu A, Kunert S, Arimondo PB, Reinhardt R, Jurkowska RZ, Jeltsch A. Emperle M, et al. Nucleic Acids Res. 2018 Apr 6;46(6):3130-3139. doi: 10.1093/nar/gky168. Nucleic Acids Res. 2018. PMID: 29518238 Free PMC article.

10

Chromatin-dependent allosteric regulation of DNMT3A activity by MeCP2.

Rajavelu A, Lungu C, Emperle M, Dukatz M, Bröhm A, Broche J, Hanelt I, Parsa E, Schiffers S, Karnik R, Meissner A, Carell T, Rathert P, Jurkowska RZ, Jeltsch A. Rajavelu A, et al. Among authors: emperle m. Nucleic Acids Res. 2018 Sep 28;46(17):9044-9056. doi: 10.1093/nar/gky715. Nucleic Acids Res. 2018. PMID: 30102379 Free PMC article.

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