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Cleavage of the fifth component of human complement and release of a split product with C5a-like activity by crystalline silica through free radical generation and kallikrein activation.
Governa M, Fenoglio I, Amati M, Valentino M, Bolognini L, Coloccini S, Volpe AR, Carmignani M, Fubini B. Governa M, et al. Among authors: valentino m. Toxicol Appl Pharmacol. 2002 Mar 15;179(3):129-36. doi: 10.1006/taap.2002.9351. Toxicol Appl Pharmacol. 2002. PMID: 11906242
Variability of biological effects of silicas: different degrees of activation of the fifth component of complement by amorphous silicas.
Governa M, Amati M, Fenoglio I, Valentino M, Coloccini S, Bolognini L, Carlo Botta G, Emanuelli M, Pierella F, Volpe AR, Astolfi P, Carmignani M, Fubini B. Governa M, et al. Among authors: valentino m. Toxicol Appl Pharmacol. 2005 Oct 1;208(1):68-77. doi: 10.1016/j.taap.2005.01.019. Toxicol Appl Pharmacol. 2005. PMID: 16164962
505 results