Osborne DF - Search Results

1

Severe immunosuppression and not a cytokine storm characterizes COVID-19 infections.

Remy KE, Mazer M, Striker DA, Ellebedy AH, Walton AH, Unsinger J, Blood TM, Mudd PA, Yi DJ, Mannion DA, Osborne DF, Martin RS, Anand NJ, Bosanquet JP, Blood J, Drewry AM, Caldwell CC, Turnbull IR, Brakenridge SC, Moldwawer LL, Hotchkiss RS. Remy KE, et al. Among authors: osborne df. JCI Insight. 2020 Sep 3;5(17):e140329. doi: 10.1172/jci.insight.140329. JCI Insight. 2020. PMID: 32687484 Free PMC article.

2

IL-10 Has Differential Effects on the Innate and Adaptive Immune Systems of Septic Patients.

Mazer M, Unsinger J, Drewry A, Walton A, Osborne D, Blood T, Hotchkiss R, Remy KE. Mazer M, et al. J Immunol. 2019 Oct 15;203(8):2088-2099. doi: 10.4049/jimmunol.1900637. Epub 2019 Sep 9. J Immunol. 2019. PMID: 31501258 Free PMC article.

3

A Whole Blood Enzyme-Linked Immunospot Assay for Functional Immune Endotyping of Septic Patients.

Mazer MB, C Caldwell C, Hanson J, Mannion D, Turnbull IR, Drewry A, Osborne D, Walton A, Blood T, Moldawer LL, Brakenridge S, Remy KE, Hotchkiss RS. Mazer MB, et al. J Immunol. 2021 Jan 1;206(1):23-36. doi: 10.4049/jimmunol.2001088. Epub 2020 Nov 25. J Immunol. 2021. PMID: 33239423 Free PMC article.

4

Frontline Science: Defects in immune function in patients with sepsis are associated with PD-1 or PD-L1 expression and can be restored by antibodies targeting PD-1 or PD-L1.

Patera AC, Drewry AM, Chang K, Beiter ER, Osborne D, Hotchkiss RS. Patera AC, et al. J Leukoc Biol. 2016 Dec;100(6):1239-1254. doi: 10.1189/jlb.4HI0616-255R. Epub 2016 Sep 26. J Leukoc Biol. 2016. PMID: 27671246 Free PMC article.

5

IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis.

Inoue S, Unsinger J, Davis CG, Muenzer JT, Ferguson TA, Chang K, Osborne DF, Clark AT, Coopersmith CM, McDunn JE, Hotchkiss RS. Inoue S, et al. Among authors: osborne df. J Immunol. 2010 Feb 1;184(3):1401-9. doi: 10.4049/jimmunol.0902307. Epub 2009 Dec 21. J Immunol. 2010. PMID: 20026737 Free PMC article.

6

Immunosuppression in patients who die of sepsis and multiple organ failure.

Boomer JS, To K, Chang KC, Takasu O, Osborne DF, Walton AH, Bricker TL, Jarman SD 2nd, Kreisel D, Krupnick AS, Srivastava A, Swanson PE, Green JM, Hotchkiss RS. Boomer JS, et al. Among authors: osborne df. JAMA. 2011 Dec 21;306(23):2594-605. doi: 10.1001/jama.2011.1829. JAMA. 2011. PMID: 22187279 Free PMC article.

7

Effects of age on mortality and antibiotic efficacy in cecal ligation and puncture.

Turnbull IR, Wlzorek JJ, Osborne D, Hotchkiss RS, Coopersmith CM, Buchman TG. Turnbull IR, et al. Shock. 2003 Apr;19(4):310-3. doi: 10.1097/00024382-200304000-00003. Shock. 2003. PMID: 12688540

8

Increased susceptibility to Candida infection following cecal ligation and puncture.

Davis CG, Chang K, Osborne D, Walton AH, Dunne WM, Muenzer JT. Davis CG, et al. Biochem Biophys Res Commun. 2011 Oct 14;414(1):37-43. doi: 10.1016/j.bbrc.2011.09.017. Epub 2011 Sep 12. Biochem Biophys Res Commun. 2011. PMID: 21939638 Free PMC article.

9

TLR3 agonist improves survival to secondary pneumonia in a double injury model.

Davis CG, Chang K, Osborne D, Walton AH, Ghosh S, Dunne WM, Hotchkiss RS, Muenzer JT. Davis CG, et al. J Surg Res. 2013 Jun 15;182(2):270-6. doi: 10.1016/j.jss.2012.09.039. Epub 2012 Oct 11. J Surg Res. 2013. PMID: 23083640

10

Adoptive transfer of apoptotic splenocytes worsens survival, whereas adoptive transfer of necrotic splenocytes improves survival in sepsis.

Hotchkiss RS, Chang KC, Grayson MH, Tinsley KW, Dunne BS, Davis CG, Osborne DF, Karl IE. Hotchkiss RS, et al. Among authors: osborne df. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6724-9. doi: 10.1073/pnas.1031788100. Epub 2003 May 7. Proc Natl Acad Sci U S A. 2003. PMID: 12736377 Free PMC article.

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