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TMPRSS2 and furin are both essential for proteolytic activation of SARS-CoV-2 in human airway cells.
Bestle D, Heindl MR, Limburg H, Van Lam van T, Pilgram O, Moulton H, Stein DA, Hardes K, Eickmann M, Dolnik O, Rohde C, Klenk HD, Garten W, Steinmetzer T, Böttcher-Friebertshäuser E. Bestle D, et al. Among authors: steinmetzer t. Life Sci Alliance. 2020 Jul 23;3(9):e202000786. doi: 10.26508/lsa.202000786. Print 2020 Sep. Life Sci Alliance. 2020. PMID: 32703818 Free PMC article.
Cleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitors.
Böttcher-Friebertshäuser E, Freuer C, Sielaff F, Schmidt S, Eickmann M, Uhlendorff J, Steinmetzer T, Klenk HD, Garten W. Böttcher-Friebertshäuser E, et al. Among authors: steinmetzer t. J Virol. 2010 Jun;84(11):5605-14. doi: 10.1128/JVI.00140-10. Epub 2010 Mar 17. J Virol. 2010. PMID: 20237084 Free PMC article.
135 results