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The gut microbiome switches mutant p53 from tumour-suppressive to oncogenic.
Kadosh E, Snir-Alkalay I, Venkatachalam A, May S, Lasry A, Elyada E, Zinger A, Shaham M, Vaalani G, Mernberger M, Stiewe T, Pikarsky E, Oren M, Ben-Neriah Y. Kadosh E, et al. Among authors: mernberger m. Nature. 2020 Oct;586(7827):133-138. doi: 10.1038/s41586-020-2541-0. Epub 2020 Jul 29. Nature. 2020. PMID: 32728212 Free PMC article.
A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism.
Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, Stiewe T, Oren M, Alitalo K, Pikarsky E, Ben-Neriah Y. Pribluda A, et al. Among authors: mernberger m. Cancer Cell. 2013 Aug 12;24(2):242-56. doi: 10.1016/j.ccr.2013.06.005. Epub 2013 Jul 25. Cancer Cell. 2013. PMID: 23890787 Free article.
CK1α ablation in keratinocytes induces p53-dependent, sunburn-protective skin hyperpigmentation.
Chang CH, Kuo CJ, Ito T, Su YY, Jiang ST, Chiu MH, Lin YH, Nist A, Mernberger M, Stiewe T, Ito S, Wakamatsu K, Hsueh YA, Shieh SY, Snir-Alkalay I, Ben-Neriah Y. Chang CH, et al. Among authors: mernberger m. Proc Natl Acad Sci U S A. 2017 Sep 19;114(38):E8035-E8044. doi: 10.1073/pnas.1702763114. Epub 2017 Sep 6. Proc Natl Acad Sci U S A. 2017. PMID: 28878021 Free PMC article.
p53 partial loss-of-function mutations sensitize to chemotherapy.
Klimovich B, Merle N, Neumann M, Elmshäuser S, Nist A, Mernberger M, Kazdal D, Stenzinger A, Timofeev O, Stiewe T. Klimovich B, et al. Among authors: mernberger m. Oncogene. 2022 Feb;41(7):1011-1023. doi: 10.1038/s41388-021-02141-5. Epub 2021 Dec 14. Oncogene. 2022. PMID: 34907344 Free PMC article.
Residual apoptotic activity of a tumorigenic p53 mutant improves cancer therapy responses.
Timofeev O, Klimovich B, Schneikert J, Wanzel M, Pavlakis E, Noll J, Mutlu S, Elmshäuser S, Nist A, Mernberger M, Lamp B, Wenig U, Brobeil A, Gattenlöhner S, Köhler K, Stiewe T. Timofeev O, et al. Among authors: mernberger m. EMBO J. 2019 Oct 15;38(20):e102096. doi: 10.15252/embj.2019102096. Epub 2019 Sep 4. EMBO J. 2019. PMID: 31483066 Free PMC article.
Phosphorylation Control of p53 DNA-Binding Cooperativity Balances Tumorigenesis and Aging.
Timofeev O, Koch L, Niederau C, Tscherne A, Schneikert J, Klimovich M, Elmshäuser S, Zeitlinger M, Mernberger M, Nist A, Osterburg C, Dötsch V, Hrabé de Angelis M, Stiewe T; German Mouse Clinic Consortium. Timofeev O, et al. Among authors: mernberger m. Cancer Res. 2020 Dec 1;80(23):5231-5244. doi: 10.1158/0008-5472.CAN-20-2002. Epub 2020 Sep 1. Cancer Res. 2020. PMID: 32873634
CRISPR-Cas9-based target validation for p53-reactivating model compounds.
Wanzel M, Vischedyk JB, Gittler MP, Gremke N, Seiz JR, Hefter M, Noack M, Savai R, Mernberger M, Charles JP, Schneikert J, Bretz AC, Nist A, Stiewe T. Wanzel M, et al. Among authors: mernberger m. Nat Chem Biol. 2016 Jan;12(1):22-8. doi: 10.1038/nchembio.1965. Epub 2015 Nov 23. Nat Chem Biol. 2016. PMID: 26595461 Free PMC article.
Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5.
Vogiatzi F, Brandt DT, Schneikert J, Fuchs J, Grikscheit K, Wanzel M, Pavlakis E, Charles JP, Timofeev O, Nist A, Mernberger M, Kantelhardt EJ, Siebolts U, Bartel F, Jacob R, Rath A, Moll R, Grosse R, Stiewe T. Vogiatzi F, et al. Among authors: mernberger m. Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8433-E8442. doi: 10.1073/pnas.1612711114. Epub 2016 Dec 12. Proc Natl Acad Sci U S A. 2016. PMID: 27956623 Free PMC article.
31 results