Testa JR - Search Results

1

Hypomorphic mTOR Downregulates CDK6 and Delays Thymic Pre-T LBL Tumorigenesis.

Gary JM, Simmons JK, Xu J, Zhang S, Peat TJ, Watson N, Gamache BJ, Zhang K, Kovalchuk AL, Michalowski AM, Chen JQ, Thaiwong T, Kiupel M, Gaikwad S, Etienne M, Simpson RM, Dubois W, Testa JR, Mock BA. Gary JM, et al. Among authors: testa jr. Mol Cancer Ther. 2020 Oct;19(10):2221-2232. doi: 10.1158/1535-7163.MCT-19-0671. Epub 2020 Aug 3. Mol Cancer Ther. 2020. PMID: 32747423 Free PMC article.

2

p16 alterations and deletion mapping of 9p21-p22 in malignant mesothelioma.

Cheng JQ, Jhanwar SC, Klein WM, Bell DW, Lee WC, Altomare DA, Nobori T, Olopade OI, Buckler AJ, Testa JR. Cheng JQ, et al. Among authors: testa jr. Cancer Res. 1994 Nov 1;54(21):5547-51. Cancer Res. 1994. PMID: 7923195

3

The phosphatidylinositol 3-kinase/AKT signal transduction pathway plays a critical role in the expression of p21WAF1/CIP1/SDI1 induced by cisplatin and paclitaxel.

Mitsuuchi Y, Johnson SW, Selvakumaran M, Williams SJ, Hamilton TC, Testa JR. Mitsuuchi Y, et al. Among authors: testa jr. Cancer Res. 2000 Oct 1;60(19):5390-4. Cancer Res. 2000. PMID: 11034077

4

AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells.

Tanno S, Tanno S, Mitsuuchi Y, Altomare DA, Xiao GH, Testa JR. Tanno S, et al. Among authors: testa jr. Cancer Res. 2001 Jan 15;61(2):589-93. Cancer Res. 2001. PMID: 11212254

5

RAD001 (Everolimus) delays tumor onset and progression in a transgenic mouse model of ovarian cancer.

Mabuchi S, Altomare DA, Connolly DC, Klein-Szanto A, Litwin S, Hoelzle MK, Hensley HH, Hamilton TC, Testa JR. Mabuchi S, et al. Among authors: testa jr. Cancer Res. 2007 Mar 15;67(6):2408-13. doi: 10.1158/0008-5472.CAN-06-4490. Cancer Res. 2007. PMID: 17363557

6

A novel recurrent chromosomal inversion implicates the homeobox gene Dlx5 in T-cell lymphomas from Lck-Akt2 transgenic mice.

Tan Y, Timakhov RA, Rao M, Altomare DA, Xu J, Liu Z, Gao Q, Jhanwar SC, Di Cristofano A, Wiest DL, Knepper JE, Testa JR. Tan Y, et al. Among authors: testa jr. Cancer Res. 2008 Mar 1;68(5):1296-302. doi: 10.1158/0008-5472.CAN-07-3218. Cancer Res. 2008. PMID: 18316591

7

DLX5 (distal-less homeobox 5) promotes tumor cell proliferation by transcriptionally regulating MYC.

Xu J, Testa JR. Xu J, et al. Among authors: testa jr. J Biol Chem. 2009 Jul 31;284(31):20593-601. doi: 10.1074/jbc.M109.021477. Epub 2009 Jun 4. J Biol Chem. 2009. PMID: 19497851 Free PMC article.

8

Losses of both products of the Cdkn2a/Arf locus contribute to asbestos-induced mesothelioma development and cooperate to accelerate tumorigenesis.

Altomare DA, Menges CW, Xu J, Pei J, Zhang L, Tadevosyan A, Neumann-Domer E, Liu Z, Carbone M, Chudoba I, Klein-Szanto AJ, Testa JR. Altomare DA, et al. Among authors: testa jr. PLoS One. 2011 Apr 19;6(4):e18828. doi: 10.1371/journal.pone.0018828. PLoS One. 2011. PMID: 21526190 Free PMC article.

9

Group I p21-activated kinases (PAKs) promote tumor cell proliferation and survival through the AKT1 and Raf-MAPK pathways.

Menges CW, Sementino E, Talarchek J, Xu J, Chernoff J, Peterson JR, Testa JR. Menges CW, et al. Among authors: testa jr. Mol Cancer Res. 2012 Sep;10(9):1178-88. doi: 10.1158/1541-7786.MCR-12-0082. Epub 2012 Jul 12. Mol Cancer Res. 2012. PMID: 22798428 Free PMC article.

10

NF-κB inhibition by bortezomib permits IFN-γ-activated RIP1 kinase-dependent necrosis in renal cell carcinoma.

Thapa RJ, Chen P, Cheung M, Nogusa S, Pei J, Peri S, Testa JR, Balachandran S. Thapa RJ, et al. Among authors: testa jr. Mol Cancer Ther. 2013 Aug;12(8):1568-78. doi: 10.1158/1535-7163.MCT-12-1010. Epub 2013 May 8. Mol Cancer Ther. 2013. PMID: 23657944 Free PMC article.

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