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The anticancer effect of mebendazole may be due to M1 monocyte/macrophage activation via ERK1/2 and TLR8-dependent inflammasome activation.
Blom K, Senkowski W, Jarvius M, Berglund M, Rubin J, Lenhammar L, Parrow V, Andersson C, Loskog A, Fryknäs M, Nygren P, Larsson R. Blom K, et al. Among authors: larsson r. Immunopharmacol Immunotoxicol. 2017 Aug;39(4):199-210. doi: 10.1080/08923973.2017.1320671. Epub 2017 May 4. Immunopharmacol Immunotoxicol. 2017. PMID: 28472897
Screening for phenotype selective activity in multidrug resistant cells identifies a novel tubulin active agent insensitive to common forms of cancer drug resistance.
Fryknäs M, Gullbo J, Wang X, Rickardson L, Jarvius M, Wickström M, Hassan S, Andersson C, Gustafsson M, Westman G, Nygren P, Linder S, Larsson R. Fryknäs M, et al. Among authors: larsson r. BMC Cancer. 2013 Aug 6;13:374. doi: 10.1186/1471-2407-13-374. BMC Cancer. 2013. PMID: 23919498 Free PMC article.
Iron chelators target both proliferating and quiescent cancer cells.
Fryknäs M, Zhang X, Bremberg U, Senkowski W, Olofsson MH, Brandt P, Persson I, D'Arcy P, Gullbo J, Nygren P, Schughart LK, Linder S, Larsson R. Fryknäs M, et al. Among authors: larsson r. Sci Rep. 2016 Dec 7;6:38343. doi: 10.1038/srep38343. Sci Rep. 2016. PMID: 27924826 Free PMC article.
524 results