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Iron Deficiency Anemia at Time of Vaccination Predicts Decreased Vaccine Response and Iron Supplementation at Time of Vaccination Increases Humoral Vaccine Response: A Birth Cohort Study and a Randomized Trial Follow-Up Study in Kenyan Infants.
Stoffel NU, Uyoga MA, Mutuku FM, Frost JN, Mwasi E, Paganini D, van der Klis FRM, Malhotra IJ, LaBeaud AD, Ricci C, Karanja S, Drakesmith H, King CH, Zimmermann MB. Stoffel NU, et al. Among authors: frost jn. Front Immunol. 2020 Jul 13;11:1313. doi: 10.3389/fimmu.2020.01313. eCollection 2020. Front Immunol. 2020. PMID: 32754150 Free PMC article. Clinical Trial.
Antibodies against the erythroferrone N-terminal domain prevent hepcidin suppression and ameliorate murine thalassemia.
Arezes J, Foy N, McHugh K, Quinkert D, Benard S, Sawant A, Frost JN, Armitage AE, Pasricha SR, Lim PJ, Tam MS, Lavallie E, Pittman DD, Cunningham O, Lambert M, Murphy JE, Draper SJ, Jasuja R, Drakesmith H. Arezes J, et al. Among authors: frost jn. Blood. 2020 Feb 20;135(8):547-557. doi: 10.1182/blood.2019003140. Blood. 2020. PMID: 31899794 Free PMC article.
The battle for iron in enteric infections.
Sousa Gerós A, Simmons A, Drakesmith H, Aulicino A, Frost JN. Sousa Gerós A, et al. Among authors: frost jn. Immunology. 2020 Nov;161(3):186-199. doi: 10.1111/imm.13236. Epub 2020 Aug 11. Immunology. 2020. PMID: 32639029 Free PMC article. Review.
Hepcidin-Mediated Hypoferremia Disrupts Immune Responses to Vaccination and Infection.
Frost JN, Tan TK, Abbas M, Wideman SK, Bonadonna M, Stoffel NU, Wray K, Kronsteiner B, Smits G, Campagna DR, Duarte TL, Lopes JM, Shah A, Armitage AE, Arezes J, Lim PJ, Preston AE, Ahern D, Teh M, Naylor C, Salio M, Gileadi U, Andrews SC, Dunachie SJ, Zimmermann MB, van der Klis FRM, Cerundolo V, Bannard O, Draper SJ, Townsend ARM, Galy B, Fleming MD, Lewis MC, Drakesmith H. Frost JN, et al. Med. 2021 Feb 12;2(2):164-179.e12. doi: 10.1016/j.medj.2020.10.004. Med. 2021. PMID: 33665641 Free PMC article.
Inclusion of cGAMP within virus-like particle vaccines enhances their immunogenicity.
Chauveau L, Bridgeman A, Tan TK, Beveridge R, Frost JN, Rijal P, Pedroza-Pacheco I, Partridge T, Gilbert-Jaramillo J, Knight ML, Liu X, Russell RA, Borrow P, Drakesmith H, Townsend AR, Rehwinkel J. Chauveau L, et al. Among authors: frost jn. EMBO Rep. 2021 Aug 4;22(8):e52447. doi: 10.15252/embr.202152447. Epub 2021 Jun 18. EMBO Rep. 2021. PMID: 34142428 Free PMC article.
Adaptive immunity and vaccination - iron in the spotlight.
Preston AE, Drakesmith H, Frost JN. Preston AE, et al. Among authors: frost jn. Immunother Adv. 2021 Jun 17;1(1):ltab007. doi: 10.1093/immadv/ltab007. eCollection 2021 Jan. Immunother Adv. 2021. PMID: 35919735 Free PMC article. Review.
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