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An orally available inverse agonist of estrogen-related receptor gamma showed expanded efficacy for the radioiodine therapy of poorly differentiated thyroid cancer.
Kim J, Hwang H, Yoon H, Lee JE, Oh JM, An H, Ji HD, Lee S, Cha E, Ma MJ, Kim DS, Lee SJ, Kadayat TM, Song J, Lee SW, Jeon JH, Park KG, Lee IK, Jeon YH, Chin J, Cho SJ. Kim J, et al. Among authors: hwang h. Eur J Med Chem. 2020 Nov 1;205:112501. doi: 10.1016/j.ejmech.2020.112501. Epub 2020 Jul 14. Eur J Med Chem. 2020. PMID: 32758860
Identification of Selective ERRγ Inverse Agonists.
Kim J, Im CY, Yoo EK, Ma MJ, Kim SB, Hong E, Chin J, Hwang H, Lee S, Kim ND, Jeon JH, Lee IK, Jeon YH, Choi HS, Kim SH, Cho SJ. Kim J, et al. Among authors: hwang h. Molecules. 2016 Jan 12;21(1):80. doi: 10.3390/molecules21010080. Molecules. 2016. PMID: 26771593 Free PMC article.
Synthesis and biological evaluation of novel 4-hydroxytamoxifen analogs as estrogen-related receptor gamma inverse agonists.
Kim J, Chin J, Im CY, Yoo EK, Woo S, Hwang HJ, Cho JH, Seo KA, Song J, Hwang H, Kim KH, Kim ND, Yoon SK, Jeon JH, Yoon SY, Jeon YH, Choi HS, Lee IK, Kim SH, Cho SJ. Kim J, et al. Among authors: hwang h, hwang hj. Eur J Med Chem. 2016 Sep 14;120:338-52. doi: 10.1016/j.ejmech.2016.04.076. Epub 2016 May 9. Eur J Med Chem. 2016. PMID: 27236015
Insights of a Lead Optimization Study and Biological Evaluation of Novel 4-Hydroxytamoxifen Analogs as Estrogen-Related Receptor γ (ERRγ) Inverse Agonists.
Kim J, Woo SY, Im CY, Yoo EK, Lee S, Kim HJ, Hwang HJ, Cho JH, Lee WS, Yoon H, Kim S, Kwon OB, Hwang H, Kim KH, Jeon JH, Singh TD, Kim SW, Hwang SY, Choi HS, Lee IK, Kim SH, Jeon YH, Chin J, Cho SJ. Kim J, et al. Among authors: hwang h, hwang hj, hwang sy. J Med Chem. 2016 Nov 23;59(22):10209-10227. doi: 10.1021/acs.jmedchem.6b01204. Epub 2016 Nov 9. J Med Chem. 2016. PMID: 27805390
4,759 results