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Hepatocyte pyroptosis and release of inflammasome particles induce stellate cell activation and liver fibrosis.
Gaul S, Leszczynska A, Alegre F, Kaufmann B, Johnson CD, Adams LA, Wree A, Damm G, Seehofer D, Calvente CJ, Povero D, Kisseleva T, Eguchi A, McGeough MD, Hoffman HM, Pelegrin P, Laufs U, Feldstein AE. Gaul S, et al. Among authors: hoffman hm. J Hepatol. 2021 Jan;74(1):156-167. doi: 10.1016/j.jhep.2020.07.041. Epub 2020 Aug 4. J Hepatol. 2021. PMID: 32763266 Free PMC article.
Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity.
Brydges SD, Mueller JL, McGeough MD, Pena CA, Misaghi A, Gandhi C, Putnam CD, Boyle DL, Firestein GS, Horner AA, Soroosh P, Watford WT, O'Shea JJ, Kastner DL, Hoffman HM. Brydges SD, et al. Among authors: hoffman hm. Immunity. 2009 Jun 19;30(6):875-87. doi: 10.1016/j.immuni.2009.05.005. Epub 2009 Jun 4. Immunity. 2009. PMID: 19501000 Free PMC article.
Inflammasome and IL-1beta-mediated disorders.
Hoffman HM, Wanderer AA. Hoffman HM, et al. Curr Allergy Asthma Rep. 2010 Jul;10(4):229-35. doi: 10.1007/s11882-010-0109-z. Curr Allergy Asthma Rep. 2010. PMID: 20425006 Free PMC article. Review.
Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice.
Bonar SL, Brydges SD, Mueller JL, McGeough MD, Pena C, Chen D, Grimston SK, Hickman-Brecks CL, Ravindran S, McAlinden A, Novack DV, Kastner DL, Civitelli R, Hoffman HM, Mbalaviele G. Bonar SL, et al. Among authors: hoffman hm. PLoS One. 2012;7(4):e35979. doi: 10.1371/journal.pone.0035979. Epub 2012 Apr 27. PLoS One. 2012. PMID: 22558291 Free PMC article.
From NAFLD to NASH to cirrhosis-new insights into disease mechanisms.
Wree A, Broderick L, Canbay A, Hoffman HM, Feldstein AE. Wree A, et al. Among authors: hoffman hm. Nat Rev Gastroenterol Hepatol. 2013 Nov;10(11):627-36. doi: 10.1038/nrgastro.2013.149. Epub 2013 Aug 20. Nat Rev Gastroenterol Hepatol. 2013. PMID: 23958599 Review.
NLRP3 inflammasome activation is required for fibrosis development in NAFLD.
Wree A, McGeough MD, Peña CA, Schlattjan M, Li H, Inzaugarat ME, Messer K, Canbay A, Hoffman HM, Feldstein AE. Wree A, et al. Among authors: hoffman hm. J Mol Med (Berl). 2014 Oct;92(10):1069-82. doi: 10.1007/s00109-014-1170-1. Epub 2014 May 28. J Mol Med (Berl). 2014. PMID: 24861026 Free PMC article.
184 results